L7920
β-Lactamase Blend
recombinant, expressed in E. coli
Synonym(s):
Carbapenemase, Cephalosprinase
Product Name
β-Lactamase Blend, recombinant, expressed in E. coli
recombinant
expressed in E. coli
sterility
γ-irradiated
form
lyophilized powder
storage temp.
2-8°C
Quality Level
General description
No detectable growth in tryptone soy broth at 30-35 °C for 14 days
Other Notes
600-1500 IU beta-lactamase I per vial
60-150 IU beta-lactamase II per vial
60-150 IU beta-lactamase II per vial
One unit will hydrolyze 1.0 μmole substrate per min (βI: benzylpenicillin; βII: cephalosporin C) in phosphate buffer, pH 7.0 at 25°C.
Physical form
Lyophilized powder containing sodium chloride, potassium phosphate, dipotassium phosphate and sorbitol.
Biochem/physiol Actions
β-Lactamases exhibit high carbapenemase activity. β-lactamases can destroy the β-lactam ring. True carbapenemases has the ability to hydrolyse several β-lactam ring containing carbapenems like meropenem, doripenem, imipenem and ertapenem.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
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Lisa M Miller et al.
ACS applied materials & interfaces, 11(36), 32599-32604 (2019-08-27)
Antimicrobial resistance (AMR) has been identified as a major threat to public health worldwide. To ensure appropriate use of existing antibiotics, rapid and reliable tests of AMR are necessary. One of the most common and clinically important forms of bacterial
Identification and screening of carbapenemase-producing Enterobacteriaceae
Nordmann P, et al.
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(5), 432-438 (2012)
Mechanisms and Detection of Antimicrobial Resistance
Principles and Practice of Pediatric Infectious Diseases (Fourth Edition), 1467-1478 (2017)
Matthew D Simmons et al.
Antibiotics (Basel, Switzerland), 9(10) (2020-10-03)
The misuse of antibiotics in health care has led to increasing levels of drug resistant infections (DRI's) occurring in the general population. Most technologies developed for the detection of DRI's typically focus on phenotyping or genotyping bacterial resistance rather than
Yuying Zhu et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 53(9), 927-932 (2014-01-01)
To investigate the characteristics of class I integrons among clinical multidrug-resistant Pseudomonas aeruginosa isolates, and to analyze the association between class I integrons and multidrug resistance. Pseudomonas aeruginosa strains were isolated from clinical samples, and the multidrug-resistant ones were picked
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