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Merck
CN

L7900

Sodium DL-lactate solution

synthetic, syrup, BioXtra, suitable for mouse embryo cell culture, 60 % (w/w)

Synonym(s):

DL-Lactic acid sodium salt

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About This Item

Linear Formula:
CH3CH(OH)COONa
CAS Number:
72-17-3
Molecular Weight:
112.06
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
24896486
EC Number:
200-772-0
Beilstein/REAXYS Number:
4332999
MDL number:
MFCD00065400

Key Documents

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InChI key

NGSFWBMYFKHRBD-UHFFFAOYSA-M

InChI

1S/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1

SMILES string

[Na+].CC(O)C([O-])=O

biological source

synthetic

product line

BioXtra

form

syrup

concentration

60 % (w/w)

technique(s)

cell culture | embryo: suitable

storage temp.

2-8°C

Quality Level

200

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Application

Lactic acid is an α hydroxyl carboxylic acid produced from pyruvate by the enzyme lactate dehydrogenase (LDH). This mixed isomer lactate has been qualified for use in mouse embryo culture. Lactate regulates pyruvate uptake and metabolism in the preimplantation mouse embryo.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000529088
0000529088
0000511470
0000511470
0000520184

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L J Edwards et al.
Molecular reproduction and development, 50(4), 434-442 (1998-07-21)
Although intracellular pH (pHi), is a regulator of numerous biological processes, it has received relatively little attention with regard to the physiology of the mammalian preimplantation embryo. Interestingly, there is some controversy as to whether the early embryo can recover
M Lane et al.
Biology of reproduction, 62(1), 16-22 (1999-12-28)
This study was an investigation of the interaction of lactate on pyruvate and glucose metabolism in the early mouse embryo. Pyruvate uptake and metabolism by mouse embryos were significantly affected by increasing the lactate concentration in the culture medium. In
Marek Nalos et al.
Critical care (London, England), 18(2), R48-R48 (2014-03-29)
Acute heart failure (AHF) is characterized by inadequate cardiac output (CO), congestive symptoms, poor peripheral perfusion and end-organ dysfunction. Treatment often includes a combination of diuretics, oxygen, positive pressure ventilation, inotropes and vasodilators or vasopressors. Lactate is a marker of
Emmi Helle et al.
Frontiers in cell and developmental biology, 9, 715093-715093 (2021-08-24)
Cell-cell interactions are crucial for organ development and function. In the heart, endothelial cells engage in bidirectional communication with cardiomyocytes regulating cardiac development and growth. We aimed to elucidate the organotypic development of cardiac endothelial cells and cardiomyocyte and endothelial
Liying Wang et al.
Cell proliferation, 54(8), e13080-e13080 (2021-06-23)
Cell reprogramming has significant impacts on their potential application in regenerative medicine. Chromatin remodelling plays a very important role in cell reprogramming, but its underlying mechanism remains poorly understood. RNA-seq, quantitative RT-PCR and western blot analysis were applied to study
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