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Merck
CN

L7877

Lactulose

≥95% (HPLC)

Synonym(s):

4-O-β-D-Galactopyranosyl-D-fructofuranose, 4-O-β-D-Galactopyranosyl-D-fructose

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About This Item

Empirical Formula (Hill Notation):
C12H22O11
CAS Number:
4618-18-2
Molecular Weight:
342.30
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24896485
EC Number:
225-027-7
Beilstein/REAXYS Number:
93773
MDL number:
MFCD00151469

Key Documents

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Product Name

Lactulose, ≥95% (HPLC)

InChI key

JCQLYHFGKNRPGE-WJONTELPSA-N

InChI

1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12+/m1/s1

SMILES string

OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

biological source

synthetic

assay

≥95% (HPLC)

form

powder

optical activity

[α]20/D -52.0 to -48.0 °, c = 4% (w/v) in water

color

white to off-white

mp

169  °C ((336 °F ))

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

Quality Level

200

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Biochem/physiol Actions

Lactulose is a synthetic disaccharide derived from galactose and fructose. It is not absorbed in the gut and is frequently used in the treatment of constipation and hepatic encephalopathy. Studies have reported that lactulose administration may cause an increase in fecal nitrogen. It is also known to function as a prebiotic. Lactulose measurements can be used to detect gastrointestinal dysfunctions.

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000484918
0000484918
0000486766
0000486766
0000479458

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Huifang Yin et al.
Carbohydrate research, 465, 58-65 (2018-06-27)
Oligosaccharides derived from lactulose (β-D-Galp-(1 → 4)-D-Fru) are drawing more and more attention nowadays because of their strong resistance to gut digestion, and the interest to discover novel prebiotics. Compared to galactooligosaccharides, currently known structures of lactulose oligosaccharides are very limited. In
Tara Raftery et al.
United European gastroenterology journal, 3(3), 294-302 (2015-07-03)
Vitamin D (vitD) supplementation may prolong remission in Crohn's disease (CD); however, the clinical efficacy and mechanisms are unclear. To determine changes in intestinal permeability (IP), antimicrobial peptide (AMP) concentrations and disease markers in CD, in response to vitD supplementation.
B Le Nevé et al.
The American journal of gastroenterology, 108(5), 786-795 (2013-04-17)
The aim of the present pilot study was to evaluate the usefulness of a test meal containing lactulose in the non-invasive assessment of visceral sensitivity in irritable bowel syndrome (IBS), and to identify subsets of IBS patients based on gastrointestinal
C P Kelly et al.
Alimentary pharmacology & therapeutics, 37(2), 252-262 (2012-11-21)
Coeliac disease, an autoimmune disorder triggered by gluten ingestion, is managed by a gluten-free diet (GFD), which is difficult for many patients. Larazotide acetate is a first-in-class oral peptide that prevents tight junction opening, and may reduce gluten uptake and
R Mathur et al.
The Journal of clinical endocrinology and metabolism, 98(4), E698-E702 (2013-03-28)
Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects. The objective of the study
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