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L7022

Sigma-Aldrich

Sodium L-lactate

~98%

Synonym(s):

(S)-2-Hydroxypropionic acid sodium salt, L-Lactic acid sodium salt, Sarcolactic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C3H5NaO3
CAS Number:
867-56-1
Molecular Weight:
112.06
Beilstein:
4567087
EC Number:
212-762-3
MDL number:
MFCD00066576
UNSPSC Code:
12352201
PubChem Substance ID:
24896392
NACRES:
NA.25

biological source

synthetic (chemical)

Quality Level

200

Assay

~98%

form

powder or crystals

color

white to faint yellow

mp

163-165 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

[Na+].C[C@H](O)C([O-])=O

InChI

1S/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1/t2-;/m0./s1

InChI key

NGSFWBMYFKHRBD-DKWTVANSSA-M

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General description

Sodium L-lactate, an organic acid derived from L-lactic acid, naturally occurs in the body, contributing to pH regulation, acid-base equilibrium, and various physiological processes, including energy metabolism through the Cori cycle. Its versatile properties extend to antimicrobial action by creating an acidic environment that inhibits harmful bacterial growth. In metabolic pathways, Sodium L-lactate exhibits efficient conversion for energy production, potentially surpassing glucose uptake in certain instances, utilizing fatty acids as an alternative fuel source, and stimulating mitochondria for enhanced ATP production, indicating a role in optimizing cellular energy efficiency. Moreover, research suggests neuroprotective capabilities, safeguarding neuronal cells from high-fat diet-induced death and addressing potential links to obesity-related neurodegenerative issues.

This multifaceted nature of Sodium L-lactate positions it as a valuable molecule for research in cellular metabolism, neuroprotection, antimicrobial, and nutritional science, where its diverse properties, including efficient energy conversion, neuroprotective effects, and potent antimicrobial activity contribute to a deeper understanding across these scientific domains.

Application

Sodium L-lactate has been used:
  • as a medium supplement and cell fuel source for human mammary epithelial cell line(MCF10A) and dendritic cell culture
  • as a gluconeogenic substrate in hepatic glucose production assay in primary hepatocytes
  • in the glucose production medium for glucose production assay in human embryonic kidney (HEK293T) cells
  • as a standard for calibration in lactate assay in bone marrow-derived macrophages

Biochem/physiol Actions

L-lactate is produced from pyruvate by the enzyme lactate dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells.

Features and Benefits

Versatile and adaptable for a wide variety of laboratory and research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function
Galan-Davila AK, et al.
The Journal of Biological Chemistry, jbc-RA118 (2018)
Lactate is always the end product of glycolysis
Rogatzki MJ, et al.
Frontiers in Neuroscience, 9, 22-22 (2015)
Etomoxir inhibits macrophage polarization by disrupting CoA homeostasis
Divakaruni AS, et al.
Cell Metabolism, 28(3), 490-503 (2018)
Latent, Immunosuppressive Nature of Poly (lactic-co-glycolic acid) Microparticles
Allen RP, et al.
ACS biomaterials science & engineering, 4(3), 900-918 (2018)
Riley P Allen et al.
ACS biomaterials science & engineering, 4(3), 900-918 (2018-12-18)
Use of biomaterials to spatiotemporally control the activation of immune cells is at the forefront of biomedical engineering research. As more biomaterial strategies are employed for immunomodulation, understanding the immunogenicity of biodegradable materials and their byproducts is paramount in tailoring
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