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L5908

Sigma-Aldrich

Lacto-N-fucopentaose I

from human milk, ≥90% (HPAE/PAD)

Synonym(s):

α-L-Fuc (1→2)-β-D-Gal-(1→3)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-D-Glc, LNFP I

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About This Item

Empirical Formula (Hill Notation):
C32H55NO25
CAS Number:
Molecular Weight:
853.77
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:

biological source

human milk

Assay

≥90% (HPAE/PAD)

storage temp.

2-8°C

SMILES string

C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]2O[C@H]3[C@H](O)[C@@H](CO)O[C@@H](O[C@H]4[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)[C@@H]4O)[C@@H]3NC(C)=O)[C@@H](O)[C@H](O)[C@@H]1O

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Other Notes

Blood group H-active pentasaccharide.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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S Lindenberg et al.
Journal of reproduction and fertility, 83(1), 149-158 (1988-05-01)
Seven oligosaccharides isolated from human milk were tested for their effect in an in-vitro model of mouse blastocyst adhesion and trophoblast outgrowth on endometrial epithelial monolayers. One compound, lacto-N-fucopentaose I (LNF I), produced a significant reduction in the percentage of
Andrew Almond et al.
Biochemistry, 43(19), 5853-5863 (2004-05-12)
Fucosylated O- and N-linked glycans are essential recognition molecules in plants and animals. To understand how they impart their functions, through interactions with proteins, requires a detailed analysis of structure and dynamics, but this is presently lacking. In this study
T Yamagata et al.
Biochemical and biophysical research communications, 181(3), 1004-1009 (1991-12-31)
Mouse embryos at implantation stage were stained successfully with lacto-N-fucopentaose I (LNF-I) bearing neoglycoprotein labeled with rhodamine synthesized by us for the first time. The fluorescent neoglycoproteins carrying LNF-II, -III, LND-I, or LNT failed to stain the embryos. The embryo
Elin Säwén et al.
The journal of physical chemistry. B, 115(21), 7109-7121 (2011-05-07)
The conformational dynamics of the human milk oligosaccharide lacto-N-fucopentaose (LNF-1), α-L-Fucp-(1 → 2)-β-D-Galp-(1 → 3)-β-D-GlcpNAc-(1 → 3)-β-D-Galp-(1 → 4)-D-Glcp, has been analyzed using NMR spectroscopy and molecular dynamics (MD) computer simulations. Employing the Hadamard (13)C-excitation technique and the J-HMBC experiment
U Karsten et al.
British journal of cancer, 58(2), 176-181 (1988-08-01)
A monoclonal antibody recognizing the blood group H type 2 antigen has been obtained from a BALB/c mouse immunized with MCF-7 (human mammary carcinoma) cells. The specificity of this antibody (A46-B/B10, IgM, kappa) has been identified by haemagglutination tests, immunohistochemistry

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