L5412
Anti-Lymphotoxin β Receptor antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-LT-βR
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
FACS, WB
Citations:
4
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
flow cytometry: 2.5 μg using 106 cells, western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... LTBR(4055)
General description
The antibody will recognize recombinant human LT-βR. Applications include in immunoblotting, flow cytometry, and agonist activity.
Immunogen
recombinant human lymphotoxin β receptor extracellular domain expressed in NS0 cells.
Biochem/physiol Actions
Lymphotoxins (LT) alpha and beta are homologs of tumor necrosis factor. These cytokines play important role in the development and function of immune system, immune response and autoimmunity. The signaling mediated by LTβ receptor mediates autoimmune reactions and the development of secondary lymphoid organs.
Physical form
Lyophilized from 0.2 μm filtered solution of phosphate buffered saline containing carbohydrates.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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H Körner et al.
Immunology and cell biology, 74(5), 465-472 (1996-10-01)
Tumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable
Hugh McDevitt et al.
Arthritis research, 4 Suppl 3, S141-S152 (2002-07-12)
Tumor necrosis factor (TNF)-alpha and lymphotoxin (LT) alpha/beta play multiple roles in the development and function of the immune system. This article focuses on three important aspects of the effects of these cytokines on the immune response and on autoimmunity.
Role of lymphotoxin in experimental models of infectious diseases: potential benefits and risks of a therapeutic inhibition of the lymphotoxin-beta receptor pathway.
Thomas W Spahn et al.
Infection and immunity, 73(11), 7077-7088 (2005-10-22)
Yu Mikami et al.
PloS one, 9(12), e114791-e114791 (2014-12-17)
Asthma-related mortality has been decreasing due to inhaled corticosteroid use, but severe asthma remains a major clinical problem. One characteristic of severe asthma is resistance to steroid therapy, which is related to neutrophilic inflammation. Recently, the tumor necrosis factor superfamily
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Instructions
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