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L5169

Sigma-Aldrich

Anti-LXRβ (C-terminal) antibody produced in rabbit

enhanced validation

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-LXRB, Anti-Liver X receptor b, Anti-NER, Anti-NER-I, Anti-NR1H2, Anti-Nuclear receptor subfamily 1, group H, member 2, Anti-RIP15, Anti-UNR, Anti-Ubiquitously expressed nuclear receptor

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~45 kDa

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

western blot: 1:1000-1:2000 using COS7 cells expressing human LXRb

UniProt accession no.

P55055

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... NR1H2(7376)

General description

Liver X receptor β (LXRβ) is ubiquitously expressed in the body. The LXRβ gene is mapped to human chromosome 19q13.33. It belongs to the ligand-activated transcription factor family.

Specificity

Anti-LXRβ(C-terminal) specifically recognizes human LXRβ.

Application

Anti-LXRβ (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Liver X receptor β (LXRβ) is involved in cholesterol metabolism and lipoprotein remodeling. It is essential for the immune system and the central nervous system (CNS). Genetic knockout of either LXRα or LXRβ in transgenic mice results in increased amyloid plaque load. Deletion of LXRβ is implicated in anxiety, neurodegeneration in substantia nigra. It also results in impaired cerebral cortex lamination and behavior response

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
118K4762

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LXRs: The Key Regulators of Intermediary Metabolism in Metabolic Syndrome
Mehrad-Majd H, et al.
Reviews in Clinical Medicine, 4(4) (2017)
Yu-Jiao Li et al.
Journal of neuroinflammation, 16(1), 132-132 (2019-07-01)
Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the brain. Here, the modes of action of LXRs and the epigenetic mechanisms regulating LXRβ expression in anterior cingulate
Nicholas F Fitz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(20), 6862-6872 (2010-05-21)
High-fat diet and certain dietary patterns are associated with higher incidence of sporadic Alzheimer's disease (AD) and cognitive decline. However, no specific therapy has been suggested to ameliorate the negative effects of high fat/high cholesterol levels on cognition and amyloid
Xiaotang Fan et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(36), 13445-13450 (2008-09-05)
Liver X receptor (LXR) beta regulates cholesterol levels in the brain and is essential for maintenance of motor neurons in the spinal cord and dopaminergic neurons in the substantia nigra. Here, we have examined the expression pattern of LXRbeta protein
Chiara Gabbi et al.
Molecular endocrinology (Baltimore, Md.), 23(2), 129-136 (2008-12-17)
Liver X receptors, LXRalpha and LXRbeta, are nuclear receptors belonging to the large family of transcription factors. After activation by oxysterols, LXRs play a central role in the control of lipid and carbohydrate metabolism as well as inflammation. The role

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