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Safety Information

L3040

Sigma-Aldrich

L-765,314 hydrate

≥98% (HPLC), solid

Synonym(s):

(2S)-4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-2-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperazinecarboxylic acid, phenylmethyl ester hydrate

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About This Item

Empirical Formula (Hill Notation):
C27H34N6O5 · xH2O
Molecular Weight:
522.60 (anhydrous basis)
MDL number:
MFCD11045931
UNSPSC Code:
12352200
PubChem Substance ID:
24278734

Assay

≥98% (HPLC)

form

solid

solubility

DMSO: 14 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

SMILES string

O.COc1cc2nc(nc(N)c2cc1OC)N3CCN([C@@H](C3)C(=O)NC(C)(C)C)C(=O)OCc4ccccc4

InChI

1S/C27H34N6O5.H2O/c1-27(2,3)31-24(34)20-15-32(11-12-33(20)26(35)38-16-17-9-7-6-8-10-17)25-29-19-14-22(37-5)21(36-4)13-18(19)23(28)30-25;/h6-10,13-14,20H,11-12,15-16H2,1-5H3,(H,31,34)(H2,28,29,30);1H2/t20-;/m0./s1

InChI key

KQHMFDHSRXAELV-BDQAORGHSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)
rat ... Adra1a(29412) , Adra1b(24173) , Adra1d(29413)

Biochem/physiol Actions

Potent and selective α1B-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
106K46103
106K46102
106K46101
106K4610
033K4616

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