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Safety Information

L2507

Sigma-Aldrich

Lectin from Arachis hypogaea (peanut)

agarose conjugate, saline suspension

Synonym(s):

PNA, Peanut agglutinin

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

conjugate

agarose conjugate

form

saline suspension

extent of labeling

2-4 mg per mL

matrix

cross-linked 4% beaded agarose

matrix activation

cyanogen bromide

matrix attachment

amino

matrix spacer

1 atom

capacity

~1.5 mg/mL binding capacity (asialofetuin)

storage temp.

2-8°C

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Application

Used for the purification of O-linked glycoproteins.

Biochem/physiol Actions

PNA does not agglutinate normal human erythrocytes, but strongly agglutinates neuraminidase treated erythrocytes. PNA has potent anti-T activity similar to the anti-T antibody in human sera. The lectin can be used to distinguish between human lymphocyte subsets.

Physical form

Suspension in 1.0 M NaCl containing 15 Mm Sodium azide.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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N Shimoda et al.
Journal of biochemistry, 102(3), 657-664 (1987-09-01)
Receptors for peanut agglutinin (PNA) were isolated from Kato III human gastric cancer cells by affinity chromatography on PNA agarose, and were labeled by the galactose oxidase-NaB3H4 method. Alkaline NaBH4 treatment of the labeled receptors released two small oligosaccharide alcohols
Jie Fan et al.
Investigative ophthalmology & visual science, 49(6), 2384-2389 (2008-02-26)
The Rpe65-/- mouse, used as a model for Leber congenital amaurosis, has slow rod degeneration and rapid cone loss, presumably because of the mistrafficking of cone opsins. This animal does not generate 11-cis retinal, and both cone loss and rod

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