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L1635

Sigma-Aldrich

L-Leucine β-naphthylamide

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Synonym(s):
L-Leucine-2-naphthylamide
Empirical Formula (Hill Notation):
C16H20N2O
CAS Number:
732-85-4
Molecular Weight:
256.34
EC Number:
211-990-0
MDL number:
MFCD00055914
UNSPSC Code:
12352204
PubChem Substance ID:
24896286
NACRES:
NA.83

Assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

H2O: insoluble

storage temp.

−20°C

SMILES string

CC(C)C[C@H](N)C(=O)Nc1ccc2ccccc2c1

InChI

1S/C16H20N2O/c1-11(2)9-15(17)16(19)18-14-8-7-12-5-3-4-6-13(12)10-14/h3-8,10-11,15H,9,17H2,1-2H3,(H,18,19)/t15-/m0/s1

InChI key

JWHURRLUBVMKOT-HNNXBMFYSA-N

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Application

L-Leucine β-naphthylamide has been used as a substrate:
  • to measure the activity of aminopeptidase in Escherichia coli
  • to evaluate the enzyme activity of cathepsin H from rabbit skeletal muscles
  • in the proteolytic assay of L-Leucine aminopeptidase

Substrate for leucine aminopeptidase determination in colorimetric and histochemical procedures.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Quality

Very low free β-naphthylamine.

Substrates

Substrate for aminopeptidase M

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Precautionary Statements

P281

Hazard Classifications

Carc. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Proteolytic activity in the placenta, decidua and postimplantation embryos of the rat.
A Fein et al.
Israel journal of medical sciences, 21(4), 394-396 (1985-04-01)
A M Reisenauer et al.
Science (New York, N.Y.), 227(4682), 70-72 (1985-01-04)
The regulation of amino-oligopeptidase (AOP), an intestinal brush border hydrolase essential for the surface digestion of peptide nutrients, was examined in rats in vivo. Short-term (30-minute) intraintestinal perfusion of a tetrapeptide substrate, Gly-Leu-Gly-Gly, or a synthetic substrate, leucyl-beta-naphthylamide, induced a
Aminopeptidase (arylamidase) activity in discrete areas of the rat brain: sex differences.
J M de Gandarias et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 21(5), 285-286 (1989-05-01)
J M de Gandarias et al.
Journal of biochemical toxicology, 7(3), 171-175 (1992-01-01)
Carbon disulfide, a volatile solvent, is widely used in industry. It has been demonstrated that it causes several neuropsychological symptoms. However, the neurochemical basis of its neurotoxic effect is relatively unknown. In this paper we have measured the effect of
Masanori Matsuishi et al.
The international journal of biochemistry & cell biology, 35(4), 474-485 (2003-02-05)
Rabbit muscle cathepsin H classified as an aminoendopeptidase was purified and its properties were investigated to clarify its contribution to the proteolysis of postmortem muscle. The purification was performed by ammonium sulfate fractionation and successive chromatographies on Sephadex G-75, phosphocelluose
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