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L1011

Sigma-Aldrich

Labetalol hydrochloride

>98% (TLC), powder

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Synonym(s):
2-Hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]benzamide hydrochloride
Empirical Formula (Hill Notation):
C19H24N2O3 · HCl
CAS Number:
32780-64-6
Molecular Weight:
364.87
EC Number:
251-211-1
MDL number:
MFCD00057663
UNSPSC Code:
12352200
PubChem Substance ID:
24278510
NACRES:
NA.77

Quality Level

200

Assay

>98% (TLC)

form

powder

color

white

solubility

H2O: soluble
ethanol: soluble

originator

Schering Plough

SMILES string

Cl.CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(N)=O

InChI

1S/C19H24N2O3.ClH/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24;/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);1H

InChI key

WQVZLXWQESQGIF-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

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Biochem/physiol Actions

Competitive β-adrenoceptor antagonist.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361f

Hazard Classifications

Repr. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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R Jaboureck-Bouttier et al.
Hypertension in pregnancy, 18(3), 239-247 (1999-12-10)
Increased lipid peroxidation is a putative causal factor for preeclampsia. Because oxygen free radicals are involved in inducing the lipid oxidation chain reaction, we evaluated two beta adrenoreceptor blockers, labetalol and metoprolol, currently used for treating hypertension with regard to
S C Fagan et al.
Experimental neurology, 150(1), 153-158 (1998-03-26)
We examined the relationship between acute hypertension following cerebral embolization and subsequent hemorrhagic transformation (HT) in a rabbit embolic stroke model. We have shown previously that the likelihood and severity of hemorrhage were significantly correlated with the magnitude of an
E Riva et al.
British journal of pharmacology, 104(4), 823-828 (1991-12-01)
1. We compared the alpha 1-, alpha 2- and beta 1-adrenoceptor blocking potencies of labetalol with those of its two stereoisomers (RR and SR) in pithed rats and in homogenized rat cerebral cortex and heart. 2. In pithed rats, labetalol
Cheryl Brandenburg et al.
Frontiers in cellular neuroscience, 14, 577858-577858 (2020-11-27)
Autism spectrum disorder (ASD) is behaviorally defined and diagnosed by delayed and/or impeded language, stereotyped repetitive behaviors, and difficulties with social interactions. Additionally, there are disruptions in motor processing, which includes the intent to execute movements, interrupted/inhibited action chain sequences
Mohamed O Amin et al.
Mikrochimica acta, 186(8), 503-503 (2019-07-05)
The use of carbon black-Fe3O4 magnetic nanocomposite (CB-Fe3O4) as a probe for surface-enhanced laser desorption ionization mass spectrometry (SELDI-MS) with a high extraction efficiency and sensitive detection is described. The magnetic nanocomposite was synthesized and fully characterized using X-ray photoelectron
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Chromatograms

application for HPLC

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