L0280
Latex beads, amine-modified polystyrene, fluorescent blue
aqueous suspension, 2.0 μm mean particle size
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About This Item
form
aqueous suspension
Quality Level
composition
Solids, 2.5%
technique(s)
cell based assay: suitable
mean particle size
2.0 μm
fluorescence
λex ~360 nm; λem ~420 nm
application(s)
cell analysis
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Application
Latex beads, amine-modified polystyrene, fluorescent blue has been used:
- as inert beads to study the role of autophagy proteins in LC3-associated phagosome (LAP) maturation
- in the culturing of peritoneal cells for phagocytic latex bead assay ex vivo
- in the preparation of LAP stimuli coated beads
Biochem/physiol Actions
Polystyrene latex beads can be used to create latex agglutination systems. Polystyrene latex beads have been used to study the transmission of Mycobacterium leprae, the causative pathogen of leprosy, as well as to develop a method for mass screening for both pulmonary and extrapulmonary tuberculosis.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Journal of Alzheimer's disease : JAD, 14(3), 345-352 (2008-07-05)
Microglial phagocytosis of amyloid-beta (Abeta) deposits is involved in Abeta clearance in vivo. To explore the ability of microglia to phagocytose beta, we cultured human microglia or human monocytic THP-1 cells directly on unfixed frontal cortex sections of an Alzheimer
Biology of reproduction, 60(3), 747-755 (1999-02-20)
To initiate normal embryonic development, an egg must receive a signal to become activated at fertilization. We here report that the ability of demembranated sperm heads to activate is abolished after incubation over the range 20-44 degreesC and is sensitive
Nature communications, 12(1), 1508-1508 (2021-03-10)
LC3-associated phagocytosis (LAP) contributes to a wide range of cellular processes and notably to immunity. The stabilization of phagosomes by the macroautophagy machinery in human macrophages can maintain antigen presentation on MHC class II molecules. However, the molecular mechanisms involved
Methods in molecular biology (Clifton, N.J.), 1519, 145-168 (2016-11-07)
The noncanonical macroautophagy pathway, LC3-associated phagocytosis (LAP) has recently emerged as an important catabolic process involved during exogenous antigen processing. It has been described that in human macrophages and dendritic cells the direct recruitment of LC3 to the phagosomal membrane
Cell chemical biology, 29(2), 239-248 (2021-08-11)
Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor on macrophages and microglia that senses and responds to disease-associated signals to regulate the phenotype of these innate immune cells. The TREM2 signaling pathway has been implicated in
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