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Safety Information

L020000

Sigma-Aldrich

TCA Deblock

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UNSPSC Code:
41116105
NACRES:
NA.21

type

for DNA synthesis, for DNA synthesis
for DNA synthesis

Quality Level

200

storage condition

dry at room temperature

concentration

28-32 g/L (TCA content, titration)

impurities

≤200 ppm water content (Karl Fischer)

color

clear
clear

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Preparation Note

Trichloroacetic acid / Dichloromethane 3/100 (v/v)

Other Notes

Deblock solution containing trichloroacetic acid (TCA) in dichloromethane removes the dimethoxytrityl (DMT) protecting group from the 5′hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

Signal Word

Danger

Hazard Classifications

Aquatic Chronic 2 - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Central nervous system, Respiratory system

WGK

WGK 2

Flash Point(F)

212.0 °F

Flash Point(C)

100 °C

Regulatory Information

危险化学品

Certificates of Analysis (COA)

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