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K3513

Sigma-Aldrich

Anti-KIF3A antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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Synonym(s):
Anti-FLA10, Anti-KLP-20
MDL number:
MFCD03791823
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

packaging

antibody small pack of 25 μL

technique(s)

immunohistochemistry: suitable using suitable for IHC on rat brain perfused with 4% paraformaldehyde
microarray: suitable
western blot: 1:2,000 using rat brain homogenate and whole cell extract of rat pheochromocytoma PC12 cell line.

UniProt accession no.

Q9Y496

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KIF3A(11127)
mouse ... Kif3a(16568)
rat ... Kif3a(84392)

General description

KIF3A/B is abundantly expressed in neuronal tissue and ubiquitously expressed in other tissues in lower amounts.
The gene KIF3A (kinesin family member 3A) is mapped to human chromosome 5q31.1. The gene encodes a subunit of heterotrimeric kinesin-2, which is a canonical plus-oriented anterograde IFT (intraflagellar transport) motor.

Immunogen

synthetic peptide corresponding to the C-terminus of mouse KIF3A (amino acids 682-701) conjugated to KLH.

Application

Anti-KIF3A antibody produced in rabbit has been used in immunohistochemistry and immunofluorescence.
Anti-KIF3A antibody produced in rabbit has been used in:
  • immunoblotting
  • immunohistochemical detection of kinesin family member 3A (KIF3A)

Biochem/physiol Actions

The gene KIF3A (kinesin family member 3A) encodes a motor subunit of kinesin-2, a protein that functions in the formation and mechanism of cilia. The chromosomal region to which the gene is mapped is linked to immune diseases, such as asthma.
The kinesin superfamily (KIFs) of proteins consists of a class of microtubule-dependent motors that plays a major role in many cellular and developmental functions, including organelle transport, mitosis, meiosis, and possibly long-range signaling in neurons. KIF3 plays a crucial role during development. KIF3A-/- and KIF3B-/- mice do not survive beyond mid-gestation. Embryos lacking KIF3A and KIF3B display randomization of left-right asymmetry and numerous morphological abnormalities. The KIF3A/B heterodimer exhibits a plus end-directed microtubule sliding activity.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A
Takeda S, et al.
The Journal of cell biology, 145(4), 825-825 (1999)
Peixuan Xia et al.
Biomedical reports, 8(4), 343-349 (2018-03-16)
Kinesin Family Member 3A (KIF3A) was recognized as a key factor of ciliogenesis and transport system of primary cilia in normal cells. However, its possible function on cancer cells has yet to be identified. In the present study, microarray tissue
High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer
Xia P, et al.
Biomedical Reports, 8(4), 343-349 (2018)
KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport.
Yamazaki H, et al.
The Journal of Cell Biology, 130(6), 1387-1399 (1995)
Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function
Jiang L, et al.
Faseb Journal (2015)
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