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K1015

Sigma-Aldrich

K114

≥98% (HPLC), powder

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Synonym(s):
(trans,trans)-1-Bromo-2,5-bis-(4-hydroxy)styrylbenzene
Empirical Formula (Hill Notation):
C22H17BrO2
CAS Number:
872201-12-2
Molecular Weight:
393.27
MDL number:
MFCD11045294
UNSPSC Code:
12352200
PubChem Substance ID:
329817123

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: soluble >10 mg/mL

storage temp.

2-8°C

SMILES string

Oc1ccc(cc1)\C=C\c2ccc(\C=C\c3ccc(O)cc3)c(Br)c2

InChI

1S/C22H17BrO2/c23-22-15-18(2-1-16-5-11-20(24)12-6-16)4-10-19(22)9-3-17-7-13-21(25)14-8-17/h1-15,24-25H/b2-1+,9-3+

InChI key

OXPHQQMZTXMEGO-RJTULKDBSA-N

Biochem/physiol Actions

K114 is a fluorescent, amyloid-specific dye, an analogue of Congo Red and BSB that recognizes amyloid lesions and allows the quantitative monitoring of the formation of amyloid fibrils assembled from the Aβ peptide, α-synuclein, and tau. The affinity for fibrils ranges 20-30 nM. Unlike the other compounds K114 has minimal fluorescence in aqueous buffers, but fluoresces brightly in the presence of amyloid fibrils. K114 can be used to monitor in vitro amyloid fibril formation by fluorescence emission at 550 nm.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319,H413

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Eric B Dammer et al.
PloS one, 7(6), e38658-e38658 (2012-07-05)
TAR DNA-binding protein 43 (TDP-43) is a major component within ubiquitin-positive inclusions of a number of neurodegenerative diseases that increasingly are considered as TDP-43 proteinopathies. Identities of other inclusion proteins associated with TDP-43 aggregation remain poorly defined. In this study
Tak-Ho Chu et al.
Journal of Alzheimer's disease : JAD, 77(3), 1315-1330 (2020-09-15)
Axonal injury has been implicated in the development of amyloid-β in experimental brain injuries and clinical cases. The anatomy of the spinal cord provides a tractable model for examining the effects of trauma on amyloid deposition. Our goal was to

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