J4705
Jatrorrhizine
from Tinospora sagittata, ≥95% (HPLC)
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7,8,13,13α-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium, Neprotin, Yatrorizine
C20H20NO4
Recommended Products
biological source
Tinospora sagittata
Assay
≥95% (HPLC)
storage temp.
2-8°C
InChI
1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1
InChI key
MXTLAHSTUOXGQF-UHFFFAOYSA-O
Biochem/physiol Actions
Phytochemical alkaloid found in medicinal plants. Anti-inflammatory. Potential therapeutic for gastrointestinal disorders.
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Talanta, 85(1), 787-793 (2011-06-08)
The fluorescence spectra of berberine, palmatine, jatrorrhizine, and coptisine in ionic liquids were studied and found to increase significantly in ionic liquids, with [C(8)MIM][PF(6)] having the greatest increase. Further studies showed that these drugs could be extracted from an aqueous
Phytotherapy research : PTR, 26(9), 1342-1347 (2012-02-02)
The inhibitory activity of Tinospora cordifolia stem-derived alkaloids was evaluated against lens aldose reductase (AR) isolated from male Wistar rats. Anticataract potential of the alkaloids of T. cordifolia was evaluated in vitro in rat lenses, considering the activity of normal
Journal of pharmaceutical and biomedical analysis, 53(3), 591-598 (2010-05-01)
A sensitive, rapid and selective liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed and validated for the simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in scutellaria-coptis herb couple in rat plasma. After protein precipitation with acetonitrile and
Analytica chimica acta, 747, 76-83 (2012-09-19)
Rhizoma coptidis, a broadly used traditional Chinese medicine, derives from the dried rhizomes of Coptis chinensis Franch, Coptis deltoidea C.Y. Cheng et Hsiao and Coptis teeta Wall. Quantitative determination of protoberberine alkaloids in R. coptidis is critical for controlling its
Biopharmaceutics & drug disposition, 33(3), 135-145 (2012-02-22)
Jatrorrhizine, a protoberberine alkaloid derived from Coptis chinensis, is currently under investigation as a natural gastric prokinetic drug candidate. In vitro and in vivo studies were conducted to characterize its pharmacokinetics and metabolism. After intravenous administration, the plasma concentration kinetics
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