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I9759

Sigma-Aldrich

Ile-Pro-Ile

≥97% (HPLC)

Synonym(s):

Diprotin A

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0.5 MG
CN¥1,327.26

CN¥1,327.26

List PriceCN¥4,424.22Save 70%

Available to ship onApril 16, 2025Details

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0.5 MG
CN¥1,327.26

About This Item

Empirical Formula (Hill Notation):
C17H31N3O4
CAS Number:
90614-48-5
Molecular Weight:
341.45
MDL number:
MFCD00038707
UNSPSC Code:
51111800
PubChem Substance ID:
24896160
NACRES:
NA.77

CN¥1,327.26

List PriceCN¥4,424.22Save 70%

Available to ship onApril 16, 2025Details

Request a Bulk Order

Assay

≥97% (HPLC)

form

powder

solubility

water: 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CCC(C)C(N)C(=O)N1CCCC1C(=O)NC(C(C)CC)C(O)=O

InChI

1S/C17H31N3O4/c1-5-10(3)13(18)16(22)20-9-7-8-12(20)15(21)19-14(17(23)24)11(4)6-2/h10-14H,5-9,18H2,1-4H3,(H,19,21)(H,23,24)

InChI key

JNTMAZFVYNDPLB-UHFFFAOYSA-N

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This Item
WH0003569M1MABF3179I2143
Monoclonal Anti-Interleukin-6 antibody produced in mouse clone 6708.11, purified immunoglobulin, lyophilized powder

I7901

Monoclonal Anti-Interleukin-6 antibody produced in mouse

Monoclonal Anti-IL6 antibody produced in mouse clone 3E4, purified immunoglobulin, buffered aqueous solution

WH0003569M1

Monoclonal Anti-IL6 antibody produced in mouse

Anti-IL-6 Antibody, clone 3A7.10

MABF3179

Anti-IL-6 Antibody, clone 3A7.10

Anti-Interleukin-6 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution

I2143

Anti-Interleukin-6 antibody produced in rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... IL6(3569)

Gene Information

human ... IL6(3569)

Gene Information

mouse ... IL6(3569)

Gene Information

human ... IL6(3569)

biological source

mouse

biological source

mouse

biological source

mouse

biological source

rabbit

clone

6708.11, monoclonal

clone

3E4, monoclonal

clone

3A7.10, monoclonal

clone

polyclonal

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

IgG fraction of antiserum

Amino Acid Sequence

Ile-Pro-Ile

Application

Ile-Pro-Ile has been used as a supplement for blood collection for hormone measurement[1] and used in Islets cell culture to stabilize glucagon-like peptide-1 (GLP-1).[2] It has also been used to inhibit the breakdown of gonadotropin-inhibitory hormone (GnIH) following serum collection.[3]

Biochem/physiol Actions

Dipeptidyl peptidase IV Inhibitor. Inhibits entry of HIV-1 or HIV-2
Inhibitor of dipeptidyl peptidase IV. Inhibits entry of HIV-1 or HIV-2 into T lymphoblastoid and monocytoid cell lines.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000289713
    0000289713
    SLCH8910
    SLBZ3509
    SLBZ0291

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    Gemma Pujadas et al.
    Molecular metabolism, 39, 101008-101008 (2020-05-12)
    Glucose-dependent insulinotropic polypeptide (GIP) conveys information from ingested nutrients to peripheral tissues, signaling energy availability. The GIP Receptor (GIPR) is also expressed in the bone marrow, notably in cells of the myeloid lineage. However, the importance of gain and loss
    F Samuel van Nierop et al.
    Clinical nutrition (Edinburgh, Scotland), 36(6), 1615-1620 (2016-10-25)
    Bile acids (BA) are pleiotropic hormones affecting glucose and lipid metabolism. The physiochemical properties of different BA species affect their enterohepatic dynamics and their affinity for bile acid receptors. The BA pool composition is altered in patients with type 2
    Effect of gonadotropin-inhibitory hormone on luteinizing hormone secretion in humans
    George JT, et al.
    Clinical Endocrinology, 86(5), 731-738 (2017)
    Lucianno Carneiro et al.
    Nutrients, 14(7) (2022-04-13)
    Nausea, vomiting and abdominal pain in diabetic patients are often attributed to diabetic gastropathy (DG). Post-pyloric ("jejunal") enteral nutrition (JN) may improve nutrition and glycaemia in difficult cases. The acute effects of JN on postprandial symptoms and gastric function in
    Carlos García-Aparicio et al.
    Journal of medicinal chemistry, 49(17), 5339-5351 (2006-08-18)
    Here we describe a novel type of enzyme-based prodrug approach in which a dipeptide moiety is linked to a nonpeptidic therapeutic drug through an amide bond which is specifically cleaved by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme activity present in
    View All Related Papers

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