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Merck
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I9409

Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster

clone 126002, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-IGF-I

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
MFCD00162566

Key Documents

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Product Name

Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster, clone 126002, purified immunoglobulin, lyophilized powder

biological source

hamster

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

126002, monoclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

capture ELISA: 2-8 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL

isotype

IgG1

UniProt accession no.

P05017

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

mouse ... Igf1(16000)

Biochem/physiol Actions

Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effects of IGF-1R signaling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Insulin-like Growth Factor-I (also known as somatomedinC and somatomedin A) and insulin-like growth factor-II(IGF-II) belong to the family of insulin-like growthfactors, which are structurally homologous to proinsulin.Mature IGF-I and IGF-II are h

Immunogen

purified, E. coli-derived recombinant mouse insulin-like growth factor-I.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ9670
MKCW0293
MKCG8144
MKCB2794V
MKBT2940V

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J Dupont et al.
Hormone research, 55 Suppl 2, 22-26 (2001-10-31)
The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) belong to the same subfamily of receptor tyrosine kinases with two extracellular alpha-subunits and two transmembrane beta-subunits. They share a high similarity of structure and intracellular signalling events.
C J Rosen
Clinical chemistry, 45(8 Pt 2), 1384-1390 (1999-08-03)
The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated
Ettore Capoluongo
The American journal of pathology, 178(1), 26-31 (2011-01-13)
Insulin and insulin-like growth factors (IGFs) are important regulators of energy metabolism and growth. Several findings have outlined an important role played by this family of molecules in both tumor maintenance and development. Despite the established contribution of the IGF

Related Content

Data Sheet - I9409

Instructions

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