I9401
Interleukin-1β human
IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
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Synonym(s):
IL-1β, Lymphocyte activating factor
MDL number:
UNSPSC Code:
12352202
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
≤12 pg/mL ED50
quality
endotoxin tested
mol wt
17.3 kDa
packaging
pkg of 5 and 25 μg
pkg of 25 μg
technique(s)
cell culture | mammalian: suitable
color
white to off-white
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL1B(3553)
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Biochem/physiol Actions
Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LAF), activates T cell lymphocytes, which then proliferate and secrete interleukin-2 (IL-2). IL-1 is released primarily from stimulated macrophages and monocytes, but has also been shown to be released from several other types and is thought to play a key role in inflammatory and immune responses. Other synonyms for IL-1 include: endogenous pyrogen (EP), mitogenic protein (MP), Helper Peak-1 (HP-1), T Cell Replacing Factor III (TRF III or TRFM), B Cell Activating Factor (BAF) and B Cell Differentiation Factor (BDF) The two closely related agents Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) share 62% homology in amino acid sequence and elicit nearly identical biological responses. IL-1α and IL-1β are both approximately 17 kDa with some heterogeneity in the amount of glycosylation.
Physical form
Lyophilized from a 0.2 μm filtered buffered solution.
Analysis Note
The biological activity is measured by the dose-dependent stimulation of MTS cleavage by murine D10S cells.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Nicholas F Lahens et al.
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Scientific reports, 11(1), 1949-1949 (2021-01-23)
Endothelial cells (EC) coordinate vascular homeostasis and inflammation. In organ transplantation, EC are a direct alloimmune target. We posited that tissue specific heterogeneity of vascular EC may partly underlie the disparate organ-specific alloimmune risk. We examined the vascular endothelial response
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