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Key Documents

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I8000

Sigma-Aldrich

2-Iodosobenzoic acid

≥98% (TLC)

Synonym(s):

IBA

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About This Item

Linear Formula:
OIC6H4CO2H
CAS Number:
304-91-6
Molecular Weight:
264.02
Beilstein:
1939973
EC Number:
206-159-4
MDL number:
MFCD00002401
UNSPSC Code:
12352209
PubChem Substance ID:
24896131
NACRES:
NA.26
Pricing and availability is not currently available.

Product Name

2-Iodosobenzoic acid,

Assay

≥98% (TLC)

form

powder

color

white to off-white

mp

230 °C (dec.) (lit.)

storage temp.

−20°C

SMILES string

OC(=O)c1ccccc1[I]=O

InChI

1S/C7H5IO3/c9-7(10)5-3-1-2-4-6(5)8-11/h1-4H,(H,9,10)

InChI key

IFPHDUVGLXEIOQ-UHFFFAOYSA-N

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technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

Quality Level

100

Quality Level

300

Quality Level

300

Quality Level

100

grade

analytical standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, TraceCERT®

grade

analytical standard

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

limited shelf life, expiry date on the label

shelf life

limited shelf life, expiry date on the label

product line

VETRANAL®

product line

-

product line

TraceCERT®

product line

-

Application

For cleavage of tryptophanyl peptide bonds.

Biochem/physiol Actions

2-Iodosobenzoic acid (IBA) may be used to study enzyme structure and activity. IBA is used as an oxidant which oxidizes vicinal sulfhydryls to disulfides (cysteine residues) within enzymes leading to their inactivation or conformational changes. IBA is also used to cleave tryptophanyl peptide bonds.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000364259
    0000341163
    0000364259
    0000341163
    SLCR5601

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    T Kleinschmidt et al.
    Biological chemistry Hoppe-Seyler, 370(8), 839-845 (1989-08-01)
    The monomeric hemoglobin fractions of Chironomus thummi thummi (CTT) and Chironomus thummi piger (CTP) differ in the ratio of their components. The determination of the primary structure of the component CTP III was achieved by automatic Edman degradation of the
    D Beale
    The International journal of biochemistry, 21(5), 549-554 (1989-01-01)
    1. Tryptic cleavage sites in bovine secretory component (SC) which become inaccessible when SC is bound to IgA dimer remained inaccessible at 60 degrees C and in 4 M urea at 37 degrees C. 2. This suggests the presence of
    S Stoeva et al.
    Biochemistry, 29(2), 527-534 (1990-01-16)
    The amino acid sequence of the neutral zinc protease from Bacillus mesentericus strain 76 (MCP 76) has been determined by using peptides derived from digests with trypsin, chymotrypsin, and cyanogen bromide and from cleavage with o-iodosobenzoic acid. The peptides were
    J M Souza et al.
    Archives of biochemistry and biophysics, 360(2), 187-194 (1998-12-16)
    Rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was inactivated by peroxynitrite under biologically relevant conditions. The decrease of enzymatic activity followed an exponential function, and the concentration of peroxynitrite needed to inactivate 50% of 7 microM GAPDH (IC50) was 17 microM. Hydroxyl
    S P Fling et al.
    Current eye research, 7(2), 191-199 (1988-02-01)
    Bovine retinal S-antigen was cleaved by three chemical cleavage procedures including o-iodosobenzoic acid (IBA), mile acid and cyanogen bromide. The resultant peptides were used to study antibody-defined epitopes. Treatment with IBA, which cleaves primarily at tryptophanyl peptide bonds, produced at
    View All Related Papers

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