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I7388

Sigma-Aldrich

Isoxanthopterin

≥97.5%, powder

Synonym(s):

2-Amino-4,7-dihydroxy-1,3,5,8-tetraazanaphthalene, 2-Amino-4,7-dihydroxypteridine, 2-Amino-4,7-pteridinediol

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About This Item

Empirical Formula (Hill Notation):
C6H5N5O2
CAS Number:
529-69-1
Molecular Weight:
179.14
Beilstein:
181594
EC Number:
208-469-5
MDL number:
MFCD00006696
UNSPSC Code:
41106305
PubChem Substance ID:
24277725
NACRES:
NA.51

Assay

≥97.5%

form

powder

color

off-white

solubility

1 M NaOH: 50 mg/mL, clear, very dark yellow

storage temp.

room temp

SMILES string

NC1=NC2=C(N=CC(=O)N2)C(=O)N1

InChI

1S/C6H5N5O2/c7-6-10-4-3(5(13)11-6)8-1-2(12)9-4/h1H,(H4,7,9,10,11,12,13)

InChI key

GLKCOBIIZKYKFN-UHFFFAOYSA-N

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Application

Isoxanthopterin is a substrate for the enzyme isoxanthopterin deaminase.

Other Notes

Product of xanthine oxidase oxidation of pterin, an enzyme involved in reactive oxygen formation.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBQ0355V
BCBP9921V
BCBH6105V
BCBB2535
1366221

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R Walter et al.
American journal of respiratory and critical care medicine, 156(6), 2006-2010 (1997-12-31)
Pulmonary endothelial dysfunction is the hallmark of acute lung injury. Impaired pulmonary endothelial nitric oxide (NO) production in this event has been described. Tetrahydrobiopterin (BH4) is an essential cofactor for NO synthase and modulator of its activity. At high local
Highly sensitive assay for xanthine oxidase activity by high-performance liquid chromatography with fluorescence detection.
T Sasaoka et al.
Journal of chromatography, 424(2), 392-397 (1988-02-26)
Yuichi Komaki et al.
Pulmonary pharmacology & therapeutics, 18(4), 297-302 (2005-03-22)
Reactive oxygen species have been reported to be involved in the airway inflammatory process of chronic obstructive pulmonary disease (COPD). The aim of this study was to quantify the activity of xanthine oxidase (XO), which generates a potent radical superoxide
S Abadeh et al.
Biochimica et biophysica acta, 1117(1), 25-32 (1992-07-21)
Xanthine oxidase was purified from human milk in yields comparable with those obtained from bovine milk. The freshly purified enzyme appeared homogeneous in gel permeation FPLC and SDS-PAGE, consistent with its being a homodimer with total M(r) 290,000 +/- 6000.
Ciarán A Smyth et al.
Journal of biomedical optics, 16(7), 077007-077007 (2011-08-03)
Optical techniques toward the realization of sensitive and selective biosensing platforms have received considerable attention in recent times. Techniques based on interferometry, surface plasmon resonance, and waveguides have all proved popular, while spectroscopy in particular offers much potential. Raman spectroscopy
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