I5385
Monoclonal Anti-Human IgG1 (Fab specific) [G1m(f)] antibody produced in mouse
clone SG-16, ascites fluid
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
secondary antibodies
clone
SG-16, monoclonal
contains
15 mM sodium azide
technique(s)
indirect ELISA: 1:5,000
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Related Categories
General description
Monoclonal Anti-Human IgG1 (mouse IgG1isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Human IgGs are glycoprotein antibodies that contain two equivalent light chains and a pair of identical heavy chains. IgGs have four distinct isoforms, ranging from IgG1 to IgG4.
Immunogen
Purified human IgG
Application
Monoclonal anti-Human IgG1 may be used for the identification of human IgG1 subclass by means of various immunoassays. It can be used in direct hemagglutination (HA) and hemagglutination inhibition (HAI) assays, immunofluorometric assay (IFMA) and detection of cytoplasmic IgG. Monoclonal anti-human IgG1 has been used in enzyme linked immunosorbent assay (ELISA).
Biochem/physiol Actions
Human IgGs regulate immunological responses to allergy and pathogenic infections. IgGs have also been implicated in complement fixation and autoimmune disorders This product clone recognizes the G1m(f) allotype and has been established as a useful human IgG1 specificity standard by the WHO/IUIS study.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation
Yamazaki R, et al.
Experimental Hematology, 39(12), 1119-1123 (2011)
Andreas Lossius et al.
Annals of clinical and translational neurology, 4(10), 756-761 (2017-10-20)
Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to multiple sclerosis (MS) and IgG levels in the cerebrospinal fluid (CSF). However, how these variants are implicated in disease mechanisms remains unknown. Here, we show that proliferating plasmablasts expressing
Allotype analysis to distinguish the origin of varicella-zoster virus immunoglobulin G after allogeneic stem cell transplantation
Yamazaki R, et al.
Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation, 19(7), 1013-1020 (2013)
Kenneth A Rogers et al.
Journal of immunology (Baltimore, Md. : 1950), 177(6), 3848-3856 (2006-09-05)
Ig Fc receptors bind to immune complexes through interactions with the Fc regions of specific Ab subclasses to initiate or inhibit the defense mechanisms of the leukocytes on which they are expressed. The mechanism of action of IgG-based therapeutic molecules
Rie Yamazaki et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19(7), 1013-1020 (2013-04-16)
Varicella-zoster virus (VZV) reactivation is a frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT). Although previous studies have revealed that cellular immunity is important for suppressing reactivation, the role of humoral immunity against VZV has been poorly evaluated. We
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