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I3636

Sigma-Aldrich

Acridine Mutagen ICR 191

Synonym(s):

6-Chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H21Cl2N3O · 2HCl
CAS Number:
17070-45-0
Molecular Weight:
451.22
Beilstein:
8176205
EC Number:
241-129-4
MDL number:
MFCD00013320
UNSPSC Code:
12171500
PubChem Substance ID:
24896042
NACRES:
NA.32

solubility

DMSO: soluble

Quality Level

200

suitability

suitable for Ames test in Salmonella and E. coli (Frameshift mutagenic standard)

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NCCCNCCCl)c2c1

InChI

1S/C19H21Cl2N3O.2ClH/c1-25-14-4-6-17-16(12-14)19(23-9-2-8-22-10-7-20)15-5-3-13(21)11-18(15)24-17;;/h3-6,11-12,22H,2,7-10H2,1H3,(H,23,24);2*1H

InChI key

LMEMIKWTNPWYMI-UHFFFAOYSA-N

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Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H300 + H310 + H330,H350

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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S De Flora et al.
Mutagenesis, 12(6), 431-435 (1997-12-31)
Multiple drug resistance (MDR) mechanisms are known to limit the effectiveness of some cancer chemotherapies, probably through enhancing P-glycoprotein-mediated drug efflux from mammalian cells. Similar mechanisms appear to act in other organisms, including bacteria, and may affect not only the
Richard Hampson et al.
Mutation research, 525(1-2), 1-9 (2003-03-26)
Mutagenesis screening, in which heritable traits are isolated following damage to the genome, is a powerful approach for investigating gene function. Among vertebrate model organisms, the zebrafish (Danio rerio) is ideally suited to mutagenesis screens. The success of large-scale screens
S A Amundson et al.
Mutation research, 284(2), 287-295 (1992-12-16)
Human lymphoblastoid cell lines derived from WI-L2 exhibit unexpected frequencies of diaminopurine (DAP) resistant mutants. The background mutant fractions of 10(-7) to 10(-8) in untreated cultures are much lower than the frequencies expected for loss of a heterozygous autosomal locus
W D Chen et al.
Journal of the National Cancer Institute, 92(6), 480-485 (2000-03-16)
Deficiency of DNA mismatch repair is a common feature of cancers exhibiting instability of microsatellite DNA sequences. Cancers with microsatellite instability are recognizable by their high rate of spontaneous frameshift mutations within microsatellite sequences, their resistance to killing by cytotoxic
M Watanabe et al.
Mutation research, 314(1), 27-37 (1994-01-01)
The specificity of frameshift mutations induced by several classes of chemical mutagens was determined using a collection of mutant E. coli lacZ genes. This collection can detect each of five kinds of specific frameshift events by scoring Lac+ revertant colonies.
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