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Safety Information

I2785

Sigma-Aldrich

IRAK4, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

IPD1, NY-REN-64, REN64

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10 μG
CN¥3,875.95

CN¥3,875.95

Estimated to ship onJuly 30, 2025Details

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10 μG
CN¥3,875.95

About This Item

UNSPSC Code:
51111800
NACRES:
NA.32

CN¥3,875.95

Estimated to ship onJuly 30, 2025Details

New, lower price on this item!
Request a Bulk Order

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

378-512 nmol/min·mg

mol wt

~81 kDa

UniProt accession no.

Q9NWZ3

shipped in

dry ice

storage temp.

−70°C

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Gene Information

human ... IRAK4(51135)

Gene Information

human ... IRAK2(3656)

Gene Information

human ... MARK1(4139)

Gene Information

human ... STK4(6789)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

specific activity

378-512 nmol/min·mg

specific activity

5-7 nmol/min·mg

specific activity

400-541 nmol/min·mg

specific activity

952-1288 nmol/min·mg

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

Biochem/physiol Actions

IRAK4 (interleukin-1 receptor-associated kinase 4) protein contains a death domain and a kinase-like domain. IRAKs are mainly involved in toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) signaling. IRAK4 can activate NF-κB (nuclear factor κ B) and MAPK (mitogen activated protein kinase) pathways. It plays a crucial role in adaptive immunity and inflammatory responses.[1][2][3] IRAK4 mRNA levels are higher in humans suffering from Vogt-Koyanagi-Harada (VKH) disease.[1] Mutations in IRAK4 are associated with recurrent pyogenic bacterial infections in children.[4]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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    Certificates of Analysis (COA)

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    SLCG1983
    SLBM2333V
    SLBK0351V

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    Min Sun et al.
    PloS one, 9(4), e93214-e93214 (2014-04-03)
    To explore whether IRAK1 and IRAK4 are involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. Thirty-nine VKH patients and thirty-two healthy controls were included in this study. The mRNA levels of IRAK1 and IRAK4 from active VKH patients, inactive VKH
    Ryan Ferrao et al.
    Molecular cell, 55(6), 891-903 (2014-09-10)
    Trans-autophosphorylation is among the most prevalent means of protein kinase activation, yet its molecular basis is poorly defined. In Toll-like receptor and interleukin-1 receptor signaling pathways, the kinase IRAK4 is recruited to the membrane-proximal adaptor MyD88 through death domain (DD)
    Shyun Li et al.
    Proceedings of the National Academy of Sciences of the United States of America, 99(8), 5567-5572 (2002-04-18)
    Toll/IL-1 receptor family members are central components of host defense mechanisms in a variety of species. One well conserved element in their signal transduction is Ser/Thr kinases, which couple early signaling events in a receptor complex at the plasma membrane
    Nobutaka Suzuki et al.
    Trends in immunology, 23(10), 503-506 (2002-09-26)
    Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns and members of the proinflammatory interleukin-1 receptor (IL-1R) family, share homologies in their cytoplasmic domains. Engagement of members of both of these families initiates a common intracellular signaling cascade, in which MyD88
    Leah Cushing et al.
    The Journal of biological chemistry, 289(15), 10865-10875 (2014-02-26)
    IRAK4 is a central kinase in innate immunity, but the role of its kinase activity is controversial. The mechanism of activation for IRAK4 is currently unknown, and little is known about the role of IRAK4 kinase in cytokine production, particularly

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