I2516
Isocitric Dehydrogenase (NADP) from porcine heart
lyophilized powder, 20-60 units/mg protein (biuret)
Synonym(s):
threo-Ds-Isocitrate: NADP+ oxidoreductase, ICDH, IDH
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About This Item
CAS Number:
UNSPSC Code:
12352204
EC Number:
232-835-3
MDL number:
form
lyophilized powder
specific activity
20-60 units/mg protein (biuret)
composition
Protein, ~20%
storage temp.
−20°C
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Physical form
Lyophilized powder containing sodium citrate and manganous sulfate
Analysis Note
Highly purified
Essentially free of aconitase activity.
Essentially free of aconitase activity.
Other Notes
One unit will convert 1.0 μmole of isocitrate to α-ketoglutarate per min at pH 7.4 at 37°C.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Omar Abdel-Wahab et al.
Hematology. American Society of Hematology. Education Program, 2012, 56-64 (2012-12-13)
The myelodysplastic syndromes (MDS) are a clinically and cytogenetically heterogeneous group of clonal diseases characterized by ineffective hematopoiesis, peripheral blood cytopenias, and an increased risk of progression to acute myeloid leukemia. The precise molecular mechanisms behind the development of MDS
Yukinari Kato et al.
Biochemical and biophysical research communications, 433(4), 374-378 (2013-03-26)
Isocitrate dehydrogenase 2 (IDH2) mutations have been detected in gliomas, cartilaginous tumors, and acute myeloid leukemias. IDH2 mutations are specific to a single codon in the conserved and functionally important Arginine 172 (R172) or Arginine 140 (R140). To date, we
Catherine Gozé et al.
Journal of neurosurgery, 118(4), 866-872 (2013-01-22)
The molecular profile of diffuse WHO Grade II gliomas involving the insular lobe, with a possible impact on outcome, is controversial. The authors undertook this study to investigate a possible difference of molecular patterns between purely insular Grade II gliomas
Rithvik Vinekar et al.
BMC bioinformatics, 13 Suppl 17, S2-S2 (2013-01-11)
Isocitrate Dehydrogenases (IDHs) are important enzymes present in all living cells. Three subfamilies of functionally dimeric IDHs (subfamilies I, II, III) are known. Subfamily I are well-studied bacterial IDHs, like that of Escherischia coli. Subfamily II has predominantly eukaryotic members
O Zalatimo et al.
Advances in experimental medicine and biology, 779, 267-289 (2013-01-05)
Primary brain tumors constitute a substantial public health problem with 66,290 cases diagnosed in the US in 2012, and 13,700 deaths recorded. With discovery of genetic factors associated with specific brain tumor subtypes, the goal of therapy is changing from
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