I2279
IMID-4F hydrochloride
solid, solubility: >9 mg/mL in H2O, soluble
Synonym(s):
2-[N-(2,6-dichlorophenyl)-N-(4-fluorobenzyl)amino]-2-imidazoline hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C16H14Cl2FN3 ·HCl
CAS Number:
Molecular Weight:
374.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C16H14Cl2FN3.ClH/c17-13-5-2-6-14(18)15(13)22(16-20-7-8-21-16)10-11-3-1-4-12(19)9-11;/h1-6,9H,7-8,10H2,(H,20,21);1H
SMILES string
Cl[H].Fc1cccc(CN(C2=NCCN2)c3c(Cl)cccc3Cl)c1
InChI key
TWVCONNNZSKLLX-UHFFFAOYSA-N
assay
≥98%
form
solid
color
white
solubility
H2O: soluble >9 mg/mL
Biochem/physiol Actions
Novel imidazoline-based K(ATP) channel blocker.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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G A McPherson et al.
British journal of pharmacology, 128(8), 1636-1642 (1999-12-10)
1. The functional and electrophysiological effects of IMID-4F (2-[N-(2, 6-dichlorophenyl)-N-(4-flurorobenzyl)amino]imidazoline), a fluoro-benzyl derivative of clonidine, on vascular K(ATP) channels were investigated. In pig coronary artery, IMID-4F inhibited the vasorelaxation response to the K(ATP) channel opener levcromakalim with a pK(B) value
K Bell et al.
Naunyn-Schmiedeberg's archives of pharmacology, 362(2), 145-151 (2000-08-29)
In this study the activity of a number of novel imidazoline-based compounds (IMID series) was assessed by functional and binding studies to determine their actions at K(ATP) channels. The novel compounds, which we synthesised, were methoxy-, methyl-, butyl- and fluorophenyl
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