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I2142

Sigma-Aldrich

KN-62

≥95%, powder

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Synonym(s):
(S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine
Empirical Formula (Hill Notation):
C38H35N5O6S2
CAS Number:
127191-97-3
Molecular Weight:
721.84
MDL number:
MFCD00083180
UNSPSC Code:
12352200
PubChem Substance ID:
24895961
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

Assay

≥95%

form

powder

color

yellow

mp

130 °C

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
methanol: 10 mg/mL
DMSO: 12 mg/mL
chloroform: 20 mg/mL

storage temp.

−20°C

SMILES string

O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O

InChI

1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1

InChI key

RJVLFQBBRSMWHX-DHUJRADRSA-N

Gene Information

human ... P2RX7(5027)

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Biochem/physiol Actions

Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.

Features and Benefits

This compound is featured on the Ca/CaMKs and P2 Receptors: P2X Ion Channel Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Regina Stark et al.
Science immunology, 3(30) (2018-12-16)
Tissue-resident memory T cells (TRM) are noncirculating immune cells that contribute to the first line of local defense against reinfections. Their location at hotspots of pathogen encounter frequently exposes TRM to tissue damage. This history of danger-signal exposure is an
Antagonists of the P2X(7) receptor. From lead identification to drug development.
Simon D Guile et al.
Journal of medicinal chemistry, 52(10), 3123-3141 (2009-02-05)
Safina Gadeock et al.
Biochimica et biophysica acta, 1798(11), 2058-2066 (2010-07-31)
The P2X7 receptor is an extracellular ATP-gated cation channel critical in inflammation and immunity, and can be up-regulated by IFN-γ and LPS. This study aimed to examine the effect of TGF-β1 on the up-regulation of P2X7 function and expression in
Nikki Jo-Hao Weng et al.
Stem cell research, 23, 39-49 (2017-07-04)
New methods are needed to reduce dynamic blebbing which inhibits cell attachment and survival during passaging of pluripotent stem cells. We tested the hypothesis that activation of the P2X7 receptor by extracellular ATP during passaging initiates dynamic blebbing. The P2X7
Ana B Ramos-Hryb et al.
Pharmacological reports : PR, 69(6), 1240-1246 (2017-11-13)
Ursolic acid has been shown to display antidepressant-like effects in mice through the modulation of monoaminergic systems. In this study, we sought to investigate the involvement of signaling pathways on the antidepressant-like effects of ursolic acid. Mice were treated orally
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