I17002
Interleukin-2 human
IL-2, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested
Synonym(s):
Interleukin-2 human, Interleukin-2, T-cell growth factor
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About This Item
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recombinant
expressed in HEK 293 cells
Assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
≤4 ng/mL ED50
mol wt
15 kDa (glycosylated)
technique(s)
cell culture | mammalian: suitable
suitability
endotoxin tested
storage temp.
−20°C
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General description
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. It is a monomeric glycoprotein and proinflammatory cytokine, and contains four-a-helix bundles in its structure. IL-2 gene is mapped to human chromosome 4q27. Recombinant human IL-2 is expressed in human 293 cells as a glycoprotein with a calculated molecular mass of 15 kDa. This protein is manufactured in human cells using an all-human production system, with full chemically defined ingredients and with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports better stability of the protein in culture.
Biochem/physiol Actions
Interleukin-2 (IL-2) is a lymphokine that promotes the long-term proliferation of activated T cells and acts as an essential mediator of the immune response. IL-2 signals through the IL-2 receptor, majorly via the IL-2Ra subunit. IL-2 signaling via IL-2/anti-IL-2 immune complexes aids immune surveillance improvement during suppressed immunity. It also effectively controls infection. IL-2 plays a role in the activation and proliferation of natural killer (NK) cells, induces γ-inter-feron and B cell growth factor secretion and modulates the expression of the IL-2 receptor. It also elicits anti-tumor immunity. An elevated expression level of IL-2 along with other interleukins is observed in colorectal cancer.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.
Sequence
APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Physical form
Supplied as a lyophilized powder containing phosphate buffered saline.
Analysis Note
The biological activity of recombinant human IL-2 was tested in culture by measuring its ability to stimulate proliferation of the mouse CTLL-2 cells (mouse cytotoxic T cell line).
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 3
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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T D Santos et al.
Pathologica, 111(2), 62-66 (2019-08-08)
There is a need for the development of new biomarkers for diagnosis and prognosis of ovarian cancer, which can ideally serve as targets for new therapeutic modalities and individualization of treatment. The objectives of this study were to determine the
Onur Boyman et al.
Nature reviews. Immunology, 12(3), 180-190 (2012-02-22)
Interleukin-2 (IL-2) signals influence various lymphocyte subsets during differentiation, immune responses and homeostasis. As discussed in this Review, stimulation with IL-2 is crucial for the maintenance of regulatory T (T(Reg)) cells and for the differentiation of CD4(+) T cells into
Elizabeth A Tindall et al.
BMC cancer, 10, 69-69 (2010-02-27)
Chronic inflammation is considered to be implicated in the development of prostate cancer. In this study we are the first to investigate a potential association between variants in an autoimmune related region on chromosome 4q27 and prostate cancer risk. This
Human interleukin 2 (IL-2) promotion of immune regulation and clinical outcomes: a review
Capobianco MP, et al.
Journal of Cytokine Biology, 1, 109-109 (2016)
Ruimei Zhang et al.
PloS one, 13(7), e0201025-e0201025 (2018-07-20)
Interleukin 2 (IL-2) is a cytokine secreted by activated T cells. Studies exploring recombinant human interleukin 2 (rhuIL-2) as an adjunctive immunotherapeutic agent to treat tuberculosis (TB) have shown variable results; however, the true therapeutic efficacy of rhuIL-2 administration in
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