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Safety Information

I1636

Sigma-Aldrich

Anti-Human IgM (μ-chain specific) antibody produced in goat

whole antiserum

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2 ML
CN¥1,562.45

CN¥1,562.45

Available to ship onApril 24, 2025Details

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2 ML
CN¥1,562.45

About This Item

MDL number:
MFCD00162459
UNSPSC Code:
12352203
NACRES:
NA.46

CN¥1,562.45

Available to ship onApril 24, 2025Details

Request a Bulk Order

biological source

goat

Quality Level

200

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

secondary antibodies

clone

polyclonal

contains

15 mM sodium azide

technique(s)

indirect ELISA: 1:100,000

shipped in

dry ice

storage temp.

−20°C

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This Item
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Anti-Human IgM (μ-chain specific) antibody produced in goat whole antiserum

I1636

Anti-Human IgM (μ-chain specific) antibody produced in goat

Anti-Human IgM (μ-chain specific) antibody produced in rabbit whole antiserum

I9385

Anti-Human IgM (μ-chain specific) antibody produced in rabbit

Anti-Human IgM (μ-chain specific) antibody produced in goat affinity isolated antibody, lyophilized powder

I0759

Anti-Human IgM (μ-chain specific) antibody produced in goat

Anti-Human IgM (μ-chain specific) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution

I0140

Anti-Human IgM (μ-chain specific) antibody produced in rabbit

antibody form

whole antiserum

antibody form

whole antiserum

antibody form

affinity isolated antibody

antibody form

IgG fraction of antiserum

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

technique(s)

indirect ELISA: 1:100,000

technique(s)

indirect ELISA: 1:20,000

technique(s)

Ouchterlony double diffusion: suitable, quantitative precipitin assay: suitable

technique(s)

indirect ELISA: 1:100,000

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

shipped in

dry ice

shipped in

dry ice

shipped in

-

shipped in

dry ice

General description

Immunoglobulin M (IgM) is the major component of antibodies. It is the first antibody to be secreted during a primary antibody response, which is expressed in the human fetus. IgM is produced by B1 cells, which is found in blood.

Specificity

The antibody preparation is specific for human IgM when tested against purified human IgA, IgG, Bence Jones Kappa and Bence Jones Lambda light chains

Biochem/physiol Actions

IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
Immunoglobulin M (IgM) pentamer activates the classical pathway of complement activation and lysis of red blood cells. Monoclonal IgM antibodies provides protection against systemic infection and autoimmune diseases. It does not cross human placenta. IgM regulates B cell development.

Physical form

Supplied as a liquid containing 15 mM sodium azide as a preservative.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000340626
    0000340626
    0000270237
    0000223746
    0000193784

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    Role of natural and immune IgM antibodies in immune responses
    Boes M, et al.
    Molecular Immunology, 37(18), 1141-1149 (2000)
    Sherif Bayoumy et al.
    Scientific reports, 11(1), 18698-18698 (2021-09-23)
    Measurement of cardiac troponin I (cTnI) should be feasible for point-of-care testing (POCT) to diagnose acute myocardial infarction (AMI). Lateral flow immunoassays (LFIAs) have been long implemented in POCT and clinical settings. However, sensitivity, matrix effect and quantitation in lateral
    The immunological development of the human fetus
    Van FR, et al.
    The Journal of Experimental Medicine, 122(6), 1173-1188 (1965)
    José de la Fuente et al.
    F1000Research, 9, 1366-1366 (2021-08-21)
    Humans evolved by losing the capacity to synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in the development of a protective response mediated by anti-α-Gal IgM/IgG/IgA antibodies against pathogens containing this modification on membrane proteins. As an evolutionary trade-off, humans can develop
    The importance of natural IgM: scavenger, protector and regulator
    Ehrenstein MR and Notley, Clare A
    Nature Reviews: Immunology, 10(11), 778-778 (2010)
    View All Related Papers

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