I0879
Inosine 5′-triphosphate trisodium salt
≥95%
Synonym(s):
ITP
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About This Item
Empirical Formula (Hill Notation):
C10H12Na3N4O14P3
CAS Number:
Molecular Weight:
574.11
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Quality Level
Assay
≥95%
shipped in
dry ice
storage temp.
−20°C
SMILES string
[Na].OC1C(O)C(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n2cnc3C(=O)N=CNc23
InChI
1S/C10H15N4O14P3.Na.H/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20);;
InChI key
RIERCUPIZLBNFQ-UHFFFAOYSA-N
Gene Information
human ... HRAS(3265)
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Related Categories
Application
Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. ITP may be used as a substrate to study the specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to study activation of various ATPases and GTPases.
Inosine 5′-triphosphate trisodium salt has been used to investigate its influence on the chromosome aberration rate, the mitotic rate, sister-chromatid exchange (SCE) frequency, the proportion of first (X1), second (X2) and third (X3) division metaphases of human peripheral lymphocytes.
Biochem/physiol Actions
Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD). ITP can proficiently induce secretion in permeabilized cells than GTP. Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription. ITP can also replace GTP in the activation of G-protein.
Preparation Note
Prepared from Bacterial ATP
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Man Liu et al.
The Journal of biological chemistry, 278(12), 10112-10118 (2003-01-23)
Infrared spectroscopy has been used to map substrate-protein interactions: the conformational changes of the sarcoplasmic reticulum Ca(2+)-ATPase upon nucleotide binding and ATPase phosphorylation were monitored using the substrate ATP and ATP analogues (2'-deoxy-ATP, 3'-deoxy-ATP, and inosine 5'-triphosphate), which were modified
Itallo Collopy Junior et al.
FEMS yeast research, 5(10), 899-907 (2005-06-14)
Cryptococcus neoformans is the causative agent of pulmonary cryptococcosis and cryptococcal meningoencephalitis, which are major clinical manifestations in immunosuppressed patients. In the present study, a surface ATPase (ecto-ATPase) was identified in C. neoformans yeast cells. Intact yeasts hydrolyzed adenosine-5'-triphosphate (ATP)
Initiation of reovirus transcription by inosine 5'-triphosphate and properties of 7-methylinosine-capped, inosine-substituted messenger ribonucleic acids
Morgan M A and Shatkin A J
Biochemistry, 19(26), 5960-5966 (1980)
D Pollard-Knight et al.
The Biochemical journal, 245(3), 625-629 (1987-08-01)
When ATP, the normal phosphate donor for hexokinase D ('glucokinase'), is replaced by ITP, the positive co-operativity with respect to glucose disappears. This may be rationalized in relation to kinetic models for hexokinase D co-operativity, which assume that with the
A Baracca et al.
The International journal of biochemistry, 25(5), 701-706 (1993-05-01)
1. The possibility that the rate of ATP hydrolysis by F1-ATPase approaches the diffusion-controlled limits was investigated by measuring the values of kcat and kl (kcat/Km) as a function of increasing viscosity. 2. The values of kcat/Km decrease significantly with
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