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I0879

Sigma-Aldrich

Inosine 5′-triphosphate trisodium salt

≥95%

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Synonym(s):
ITP
Empirical Formula (Hill Notation):
C10H12Na3N4O14P3
CAS Number:
35908-31-7
Molecular Weight:
574.11
MDL number:
MFCD00084678
UNSPSC Code:
41106305
PubChem Substance ID:
24895910
NACRES:
NA.51

Quality Level

200

Assay

≥95%

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na].OC1C(O)C(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n2cnc3C(=O)N=CNc23

InChI

1S/C10H15N4O14P3.Na.H/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20);;

InChI key

RIERCUPIZLBNFQ-UHFFFAOYSA-N

Gene Information

human ... HRAS(3265)

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Application

Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. ITP may be used as a substrate to study the specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to study activation of various ATPases and GTPases.
Inosine 5′-triphosphate trisodium salt has been used to investigate its influence on the chromosome aberration rate, the mitotic rate, sister-chromatid exchange (SCE) frequency, the proportion of first (X1), second (X2) and third (X3) division metaphases of human peripheral lymphocytes.

Biochem/physiol Actions

Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD). ITP can proficiently induce secretion in permeabilized cells than GTP. Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription. ITP can also replace GTP in the activation of G-protein.

Preparation Note

Prepared from Bacterial ATP

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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D Pollard-Knight et al.
The Biochemical journal, 245(3), 625-629 (1987-08-01)
When ATP, the normal phosphate donor for hexokinase D ('glucokinase'), is replaced by ITP, the positive co-operativity with respect to glucose disappears. This may be rationalized in relation to kinetic models for hexokinase D co-operativity, which assume that with the
Initiation of reovirus transcription by inosine 5'-triphosphate and properties of 7-methylinosine-capped, inosine-substituted messenger ribonucleic acids
Morgan M A and Shatkin A J
Biochemistry, 19(26), 5960-5966 (1980)
Functionally nonequivalent interactions of guanosine 5?-triphosphate, inosine 5?-triphosphate, and xanthosine 5?-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes
Klinker J F and Seifert R
Biochemical Pharmacology, 54(5), 551-562 (1997)
A Baracca et al.
The International journal of biochemistry, 25(5), 701-706 (1993-05-01)
1. The possibility that the rate of ATP hydrolysis by F1-ATPase approaches the diffusion-controlled limits was investigated by measuring the values of kcat and kl (kcat/Km) as a function of increasing viscosity. 2. The values of kcat/Km decrease significantly with
Walter Steffen et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(35), 12904-12909 (2004-08-25)
The central features of the mechanical cycle that drives the contraction of muscle are two translational steps: the working stroke, whereby an attached myosin crossbridge moves relative to the actin filament, and the repriming step, in which the crossbridge returns
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