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Merck
CN

I0658

IC 261

≥98% (HPLC)

Synonym(s):

1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one, SU5607

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About This Item

Empirical Formula (Hill Notation):
C18H17NO4
CAS Number:
186611-52-9
Molecular Weight:
311.33
NACRES:
NA.77
PubChem Substance ID:
24278111
UNSPSC Code:
12352200
MDL number:
MFCD00118156
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
protect from light

Key Documents

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InChI key

JBJYTZXCZDNOJW-RAXLEYEMSA-N

SMILES string

COc1cc(OC)c(\C=C2/C(=O)Nc3ccccc23)c(OC)c1

InChI

1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10-

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

yellow

solubility

DMSO: >10 mg/mL

Quality Level

100

Gene Information

human ... CSNK1D(1453), CSNK1E(1454)

Related Categories

Biochem/physiol Actions

Casein kinase 1 δ (CK1δ) and CK1 ε inhibitor.

Physical form

Product is a mixture of the Z- and E-isomers, with the predominant isomer expected to be E.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000152262
0000152262
0000143629
0000143629
100M4624V

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Marta Vázquez-Cedeira et al.
PloS one, 6(8), e23235-e23235 (2011-08-11)
Human vaccinia-related kinases (VRK1 and VRK2) are atypical active Ser-Thr kinases implicated in control of cell cycle entry, apoptosis and autophagy, and affect signalling by mitogen activated protein kinases (MAPK). The specific structural differences in VRK catalytic sites make them
Konstantinos Gkatzis et al.
eLife, 10 (2021-09-30)
Lung epithelial progenitors differentiate into alveolar type 1 (AT1) and type 2 (AT2) cells. These cells form the air-blood interface and secrete surfactant, respectively, and are essential for lung maturation and function. Current protocols to derive and culture alveolar cells

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