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Merck
CN

I0157

Ibudilast

≥99% (HPLC), Phosphodiesterase IV inhibitor, solid

Synonym(s):

2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404

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About This Item

Empirical Formula (Hill Notation):
C14 H18 N2 O
CAS Number:
50847-11-5
Molecular Weight:
230.31
UNSPSC Code:
41106305
PubChem Substance ID:
24278482
NACRES:
NA.77
MDL number:
MFCD00864808

Key Documents

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Product Name

Ibudilast, ≥99% (HPLC), solid

SMILES string

CC(C)C(=O)c1c(nn2ccccc12)C(C)C

InChI key

ZJVFLBOZORBYFE-UHFFFAOYSA-N

InChI

1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3

assay

≥99% (HPLC)

form

solid

color

white

solubility

DMSO: soluble 28 mg/mL, H2O: soluble 4.5 mg/mL

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Related Categories

Biochem/physiol Actions

Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000536625
0000536620
0000536625
0000536620
0000511227

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Aldric T Hama et al.
Journal of neurotrauma, 29(3), 600-610 (2011-08-03)
Ibudilast, an asthma drug, has demonstrated antinociceptive effects in several rat models of peripheral neuropathic pain, and a proposed mechanism of action is the inhibition of release of the cytokine tumor necrosis factor-α (TNF-α) from activated spinal microglia. Spinal glial
Sarah E Snider et al.
European journal of pharmacology, 701(1-3), 124-130 (2013-02-05)
Neuroinflammation induced by activated microglia and astrocytes can be elicited by drugs of abuse. Methamphetamine administration activates glial cells and increases proinflammatory cytokine production, and there is recent evidence of a linkage between glial cell activation and drug abuse-related behavior.
Jennifer H Benbow et al.
The Journal of biological chemistry, 287(45), 37907-37916 (2012-09-19)
Peripheral neuropathy is one of the most severe and irreversible side effects caused by treatment from several chemotherapeutic drugs, including paclitaxel (Taxol®) and vincristine. Strategies are needed that inhibit this unwanted side effect without altering the chemotherapeutic action of these
Michelle Kiebala et al.
PloS one, 6(4), e18633-e18633 (2011-04-16)
Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorders (HAND) occur, in part, due to the inflammatory response to viral proteins, such as the HIV-1 transactivator of transcription (Tat), in the central nervous system (CNS). Given the need for novel adjunctive therapies for
Primary neuroprotection: the Holy Grail of multiple sclerosis therapy.
Robert J Fox
Neurology, 74(13), 1018-1019 (2010-03-05)
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