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HPA047192

Sigma-Aldrich

Anti-CLCA2 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-CLCRG2

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About This Item

UNSPSC Code:
51111800
Human Protein Atlas Number:
HPA047192

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000

immunogen sequence

EELTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFSPQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDYLILKGVLTAMGL

UniProt accession no.

Q9UQC9

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CLCA2(9635)

General description

Calcium activated chloride channel 2(CLCA2) is an integral transmembrane protein. CLCA2 is induced during human mammary epithelial cell differentiation. CLCA2 is located on human chromosome 1p22.3.

Immunogen

chloride channel accessory 2

Application

Anti-CLCA2 antibody has been used to detect CLCA2 in nasopharyngeal carcinoma(NPC) cell lines. It also has been used to detect CLCA2 in SiHa cells and tumor tissues using western blotting.

Biochem/physiol Actions

CLCA2 regulates cell migration and invasion and is also associated with p53 tumour suppressor genes. CCLA2 helps to maintain corneal transparency due to the high and tissue specific expression of CCLA2 gene in human corneal epithelium. CLCA2 plays an important role in suppressing breast cancer. CLCA2 is used as an effective immunohistochemical marker for distinguishing primary SCC and primary ADC of lungs.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST71988

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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CLCA2, a novel RUNX1 partner gene in a therapy-related leukemia with t (1; 21)(p22; q22)
Giguere A, et al.
Cancer Genetics and Cytogenetics, 202(2), 94-100 (2010)
CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer
Li, Xiuro, et al.
Oncogene, 23(7), 1474-1474 (2004)
CLCA2 as a novel immunohistochemical marker for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the lung
Shinmura,, et al.
Disease Markers, 2014 (2014)
Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling
Qiang, Yu, et al.
Journal of Experimental & Clinical Cancer Research, 37(1), 34-34 (2018)
Isocorydine induces cell differentiation through reversed epithelial mesenchymal transition in SiHa cells
Liang, Xu, et al.
International Journal of Clinical and Experimental Medicine, 11(8), 7811-7820 (2018)
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