HPA043237
Anti-APOBEC3A antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
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All Photos(3)
Synonym(s):
Anti-Apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3a, Anti-Arp3, Anti-Phrbn
UNSPSC Code:
12352203
Human Protein Atlas Number:
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biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
recombinant expression
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry: 1:1000-1:2500
western blot: 0.04-0.4 μg/mL
immunogen sequence
EASPASGPRHLMDPHIFTSNFNNGIGR
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... APOBEC3A(200315)
General description
The gene APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) is mapped to human chromosome 22q13.1. The protein has a catalytically active deaminase domain. It belongs to the APOBEC3 genes family.
Immunogen
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A recombinant protein epitope signature tag (PrEST)
Application
All Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-APOBEC3A antibody produced in rabbit has been used in immunohistochemistry.
Anti-APOBEC3A antibody produced in rabbit has been used in immunohistochemistry.
Anti-APOBEC3A antibody produced in rabbit has also been used in immunofluorescence staining.
Biochem/physiol Actions
APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) is a cytidine deaminase. APOBEC3 proteins are mainly involved in intracellular antiviral defense responses, particularly against retroviruses. They are also involved in carcinogenesis by dC (deoxycytidine) deamination, thereby causing DNA mutations. APOBEC3A also exhibits mRNA-editing function. It is involved with guanine-to-alanine editing in transcripts of WT1 (wilms tumor 1). Deletion in APOBEC3A gene is associated with breast cancer predisposition. This happens due to increased stability of APOBEC3A mRNA.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST83236
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population.
Marouf C, et al.
BMC Cancer, 16, 165-165 (2016)
Makoto Kano et al.
International journal of cancer, 145(6), 1547-1557 (2019-06-23)
Human papillomavirus (HPV) has been identified as a causative agent of cervical cancer and oropharyngeal cancer (OPC). Intriguingly, estrogen and HPV were shown to play synergistic roles in cervical carcinogenesis. We recently demonstrated that the apolipoprotein B mRNA-editing catalytic polypeptide
APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts.
Niavarani A, et al.
PLoS ONE, 10, e0120089-e0120089 (2015)
APOBEC3A associates with human papillomavirus genome integration in oropharyngeal cancers.
Kondo S, et al.
Oncogene, doi: 10-doi: 10 (2016)
Activation of DNA damage repair factors in HPV positive oropharyngeal cancers
Kono T, et al.
Virology (2020)
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