HPA036774
Anti-NKX6-1 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-NK6 homeobox 1, Anti-NKX6A, Anti-Nkx6.1
Product Name
Anti-NKX6-1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
immunogen sequence
PLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSM
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NKX6-1(4825)
Application
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-NKX6-1 antibody has been used in immunofluorescence, FAIRE (formaldehyde-assisted isolation of regulatory elements) and ChIP and immunohistochemistry.
Anti-NKX6-1 antibody has been used in immunofluorescence, FAIRE (formaldehyde-assisted isolation of regulatory elements) and ChIP and immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Chromatin immunoprecipitation (1 paper)
Chromatin immunoprecipitation (1 paper)
Biochem/physiol Actions
NKX6-1 (NK6 homeobox 1) is involved in the growth and modulation of endocrine activities of pancreatic islets. It acts as an immunohistochemical marker for pancreatic and duodenal neuroendocrine tumors. NKX6-1 also participates in lineage specification in early pancreatic progenitor tissue. This gene regulates the expression of several pancreas-related genes.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
General description
NKX6-1 (NK6 homeobox 1), a homeobox transcription factor is coded by NKX6A gene. It is located on human chromosome 4q21.2-q22. NKX6-1 belongs to the NK homeobox gene family. It is specific in adult cells producing insulin.
Immunogen
NK6 homeobox 1 recombinant protein epitope signature tag (PrEST)
Other Notes
Corresponding Antigen APREST80893
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
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Noémie Mlp Bérenger-Currias et al.
Journal of tissue engineering, 13, 20417314221103042-20417314221103042 (2022-06-17)
Stem-cell derived in vitro systems, such as organoids or embryoids, hold great potential for modeling in vivo development. Full control over their initial composition, scalability, and easily measurable dynamics make those systems useful for studying specific developmental processes in isolation.
Duo An et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(2), E263-E272 (2017-12-28)
Cell encapsulation has been shown to hold promise for effective, long-term treatment of type 1 diabetes (T1D). However, challenges remain for its clinical applications. For example, there is an unmet need for an encapsulation system that is capable of delivering
NKX6-1 is a novel immunohistochemical marker for pancreatic and duodenal neuroendocrine tumors.
Tseng IC, et al.
American Journal of Surgical Pathology, 39(6), 850-857 (2015)
Isolation, characterization, and chromosomal mapping of the human Nkx6. 1 gene (NKX6A), a new pancreatic islet homeobox gene.
Inoue H, et al.
Genomics, 40(2), 367-370 (1997)
Generation of thalamic neurons from mouse embryonic stem cells.
Shiraishi A, et al.
Development, 144, 1211-1220 (2017)
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