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HPA028658

Sigma-Aldrich

Anti-PIP4K2C antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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Synonym(s):
Anti-C15orf6, Anti-FLJ22055, Anti-PDRC2, Anti-PIP5K2C, Anti-RHGK, Anti-SLC42A3, Anti-phosphatidylinositol-5-phosphate 4-kinase, type II, γ
UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunohistochemistry: 1:200- 1:500

immunogen sequence

LEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLI

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PIP4K2C(79837)

General description

PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 γ) belongs to the phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) family. It is expressed at high levels in the brain. PIP4K2C is located on human chromosome 12q13.3.

Immunogen

phosphatidylinositol-5-phosphate 4-kinase, type II, gamma recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) modulates the levels of their substrate, PI5P. It participates in the metabolic control, growth control, and several stress responses. Absence of PIP4K2C leads to hyperactivation of the immune system.Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) helps in the conversion of phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST73852

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hyeseok Shim et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(27), 7596-7601 (2016-06-18)
Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three enzymes PI5P4Kα, PI5P4Kβ, and PI5P4Kγ, and these enzymes have been implicated in metabolic control, growth control, and a variety of stress responses. Here, we show that mice with
Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.
Shim H, et al.
Proceedings of the National Academy of Sciences of the USA, 113(27), 7596-7601 (2016)
Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13. 2 and 12q24. 13 as type I diabetes loci, and support for a new locus, 12q13. 3?q14. 1.
Cooper JD, et al.
Genes and Immunity, 10(S1), S95-S95 (2009)
The function of phosphatidylinositol 5-phosphate 4-kinase ? (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site.
Clarke JH, et al.
The Biochemical Journal, 466(2), 359-367 (2015)

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