HPA023644
Anti-STAR antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, ab1
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Synonym(s):
Anti-NET29, Anti-STARD1, Anti-TMPIT, Anti-steroidogenic acute regulatory protein
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
independent
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry: 1:200-1:500
immunogen sequence
QDNGDKVMSKVVPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELA
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... STAR(6770)
Related Categories
General description
Steroidogenic acute regulatory protein is located on human chromosome 8p11.2.
Immunogen
steroidogenic acute regulatory protein recombinant protein epitope signature tag (PrEST)
Application
Anti-STAR antibody produced in rabbit has been used to detect StAR in Paraffin-embedded adrenal samples using immunohistochemistry.
Biochem/physiol Actions
Steroidogenic acute regulatory protein (StAR) is essential for the transfer of cholesterol to mitochondria for adrenal and gonadal steroidogenesis. StAR gene analysis can help in the diagnosis of lipoid congenital adrenal hyperplasia (LCAH). It is also identified that activins A,B,AB downregulates StAR and thereby reduces the production of progesterone in human granulosa cells. Hypoxia mediated upregulation of StAR stimulates the synthesis of aldosterone in pulmonary artery endothelial cells which contributes to pulmonary vascular fibrosis. Activation of StAR helps in prevention of atherosclerotic cardiovascular disease.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST76259
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Clinical features and StAR gene mutations in children with congenital lipoid adrenal hyperplasia
Xie, Ting, et al.
Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 17(5), 472-476 (2015)
Role of the steroidogenic acute regulatory protein in health and disease
Manna, Pu, et al.
Endocrine, 51(1), 7-21 (2016)
The emerging role of the molecular marker p27 in the differential diagnosis of adrenocortical tumors
Pereira,, et al.
Endocrine Connections, EC-13 (2013)
Effect of the NBD-group position on interaction of fluorescently-labeled cholesterol analogues with human steroidogenic acute regulatory protein STARD1
Tugaeva,, et al.
Biochemical and Biophysical Research Communications, 497(1), 58-64 (2018)
Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis
Maron, Br, et al.
Circulation, CIRCULATIONAHA-CIRCULATION113 (2014)
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