Anti-SPHK1 antibody produced in rabbit

SPHK1 (Sphingosine kinase 1) is a lipid kinase consisting of two domains and a catalytic site located in the cleft between the two domains and a hydrophobic lipid-binding chamber placed in the C-terminal domain.

Sphingosine kinase 1 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

SPHK1 (Sphingosine kinase 1) is associated with several cellular functions such as cell signaling, cell apoptosis, the production of pro-inflammatory response, immunomodulation, and control of vascular integrity. It identifies the lipid substrate and catalyzes ATP-dependent phosphorylated conversion of sphingosine to sphingosine-1-phosphate (S1P). S1P acts in the cell signaling pathway intracellularly and extracellularly as a receptor ligand. It has been reported that the protein plays an important role in lymphocyte trafficking, angiogenesis, and response to apoptotic stimuli. Studies have suggested application of SPHK1 in the field of drug discovery.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST75839.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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