Anti-BAZ2B antibody produced in rabbit

BAZ2B (Bromodomain adjacent to zinc finger domain, 2B) is a novel member of bromodomain family mapped to chromosome 2q23-q24. It is composed of a carboxy-terminal bromodomain, an adjacent PHD finger, and a WACZ motif. Apart from these, it also consists of at least four other conserved novel motifs.

Bromodomain adjacent to zinc finger domain protein 2B recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

BAZ2B (Bromodomain adjacent to zinc finger domain, 2B) participates in chromatin-dependent regulation of transcription as an integral subunit of chromatin remodeling complexes. It exerts histone acetyltransferase activity. It also plays a vital role in cardiac biology and alteration in its chromosomal location has been reported in sudden cardiac death (SCD). Bromodomain proteins identify and bind to the e-N-lysine acetylation motifs during protein interaction.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST73703

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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