Anti-BEND3 antibody produced in rabbit

BEN domain-containing protein 3 (BEND3) is localized in the nucleoli of cells. This heterochromatin-associated protein possesses three amino acid residues at the amino-terminal region which functions as a nuclear localization signal (NLS).

BEN domain-containing protein 3 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

BEN domain-containing protein 3 (BEND3) plays a role as a transcriptional repressor in the nucleus wherein it binds to ribosomal RNA (rRNA) gene promoters to aid in suppressing rRNA genes. Loss of function of BEND3 has shown a decrease in the methylation of rDNA promoters. The protein associates with the nucleolar-remodeling complex (NoRC) and in its SUMOylated form, it associates with ubiquitin specific protease 21 (USP21) debiquitinase. Its overexpression causes early chromatin condensation and vigorous heterochromatinization, leading to cell cycle arrest.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST72814

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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