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HPA013189

Sigma-Aldrich

Anti-TCF21 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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Synonym(s):
Anti-POD1, Anti-bHLHa23, Anti-transcription factor 21
UNSPSC Code:
12352203
Human Protein Atlas Number:
HPA013189

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200

immunogen sequence

LSDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQV

UniProt accession no.

O43680

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TCF21(6943)

General description

Transcription factor TCF21 (TCF21) or capsulin, expressed in proepicardial cells is mapped to human chromosome 6q23.2.

Immunogen

transcription factor 21 recombinant protein epitope signature tag (PrEST)

Application

Anti-TCF21 antibody produced in rabbit has been used in:
  • immunofluorescence
  • flow cytometry
  • chromatin immunoprecipitation

Biochem/physiol Actions

Transcription factor TCF21 (TCF21) regulates mesenchymal-to-epithelial differentiation and smooth muscle cells (SMCs) phenotypic modulation. The deletion of TCF21 gene leads to SMC upregulation. Hypermethylation of TCF21 is implicated in non-small cell lung cancer (NSCLC). TCF21 is a tumor suppressor and is involved in the invasion and metastasis. Elevated expression of TCF21 leads to hepatocellular cancer suppression. It also elicits anti-angiogenic activity in cholangiocarcinoma. TCF21 locus is also associated with coronary heart disease(CAD).

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST85233

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Regulatory Information

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Felix Kliewe et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 55(S4), 48-67 (2021-06-21)
Podocyte differentiation is essential for proper blood filtration in the kidney. It is well known that transcription factors play an essential role to maintain the differentiation of podocytes. The present study is focused on the basic helix-loop-helix (bHLH) transcription factor
Juyong Brian Kim et al.
PLoS genetics, 13(5), e1006750-e1006750 (2017-05-10)
Both environmental factors and genetic loci have been associated with coronary artery disease (CAD), however gene-gene and gene-environment interactions that might identify molecular mechanisms of risk are not easily studied by human genetic approaches. We have previously identified the transcription
Quanyi Zhao et al.
Genome biology, 21(1), 135-135 (2020-06-10)
To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with three stages of transcriptional cis-regulation in primary
Olga Sazonova et al.
PLoS genetics, 11(5), e1005202-e1005202 (2015-05-29)
To functionally link coronary artery disease (CAD) causal genes identified by genome wide association studies (GWAS), and to investigate the cellular and molecular mechanisms of atherosclerosis, we have used chromatin immunoprecipitation sequencing (ChIP-Seq) with the CAD associated transcription factor TCF21
Quanyi Zhao et al.
Genome medicine, 11(1), 23-23 (2019-04-25)
Genome-wide association studies have identified over 160 loci that are associated with coronary artery disease. As with other complex human diseases, risk in coronary disease loci is determined primarily by altered expression of the causal gene, due to variation in
View All Related Papers

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