Anti-CLCC1 antibody produced in rabbit

CLCC1 (chloride channel CLIC like 1) is an intracellular chloride channel, which belongs to the CLIC channel family. This protein is composed of 551 amino acids, and is thought to have four transmembrane domains. Its mRNA is expressed at high levels in testis, and is moderately expressed in brain, heart, lung, kidney, liver and spleen. It localizes to Golgi bodies, nucleus and ER (endoplasmic reticulum), and is related to Mid-1 protein of Saccharomyces cerevisiae. This gene localizes to human chromosome 1.

Mid-1-related chloride channel 1 isoform 1 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

CLCC1 (chloride channel CLIC like 1) functions as an anion channel. Inactivation of this protein in ER (endoplasmic reticulum) results in increase of HSP70 (heat shock protein) family member GRP78. This results in the accumulation of ubiquitinated proteins in neurons leading to degeneration. Thus, chloride homeostasis is essential for the proper protein-folding functionality of ER.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST71867

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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