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HMI0372

Sigma-Aldrich

MISSION® microRNA Mimic

hsa-miR-21*

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Synonym(s):
hsa-miR-21-3p
UNSPSC Code:
12352200
miRNA ID:
hsa-mir-21 Sanger Database
NACRES:
NA.51

product line

MISSION®

form

solid

mature sequence

CAACACCAGUCGAUGGGCUGU

Sanger mature/minor accession no.

MIMAT0004494

Sanger microRNA accession no.

MI0000077

storage temp.

−20°C

Gene Information

human ... hsa-miR-21*(406991)

General description

The ready-to-use MISSION miRNA mimics are small, double-stranded RNA molecules designed to mimic endogenous mature miRNA molecules when introduced into cells. miRNA are known to regulate gene expression in a variety of manners, including translational repression, mRNA cleavage and deadenylation. MISSION miRNA Mimics, a member of MISSION RNAi product family, provides miRNA researchers with a range of options from individual MISSION mimics to a full library of human miRNA mimics based on latest version of miRBase (currently hosted by the University of Manchester, previously hosted by the Sanger Institute).

  • Optimized and ready for transfection.
  • Novel MISSION miRNA mimic design has been functionally tested for knockdown efficiency against natural miRNA targets.
  • Unique MISSION miRNA mimic design significantly reduces possible sense strand off target effects.
  • Available as a whole human library and individual miRNA targets.

Other Notes

miRBase V18 Mature ID update: hsa-miR-21-3p

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Hao-Yu Chuang et al.
Journal of clinical medicine, 8(7) (2019-07-05)
The tumor microenvironment (TME) plays a crucial role in virtually every aspect of tumorigenesis of glioblastoma multiforme (GBM). A dysfunctional TME promotes drug resistance, disease recurrence, and distant metastasis. Recent evidence indicates that exosomes released by stromal cells within the

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