Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

HMI0371

Sigma-Aldrich

MISSION® microRNA Mimic

hsa-miR-21

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
hsa-miR-21-5p
UNSPSC Code:
12352200
miRNA ID:
hsa-mir-21 Sanger Database
NACRES:
NA.51

product line

MISSION®

form

solid

mature sequence

UAGCUUAUCAGACUGAUGUUGA

Sanger mature/minor accession no.

MIMAT0000076

Sanger microRNA accession no.

MI0000077

storage temp.

−20°C

Gene Information

General description

The ready-to-use MISSION miRNA mimics are small, double-stranded RNA molecules designed to mimic endogenous mature miRNA molecules when introduced into cells. miRNA are known to regulate gene expression in a variety of manners, including translational repression, mRNA cleavage and deadenylation. MISSION miRNA Mimics, a member of MISSION RNAi product family, provides miRNA researchers with a range of options from individual MISSION mimics to a full library of human miRNA mimics based on latest version of miRBase (currently hosted by the University of Manchester, previously hosted by the Sanger Institute).

  • Optimized and ready for transfection.
  • Novel MISSION miRNA mimic design has been functionally tested for knockdown efficiency against natural miRNA targets.
  • Unique MISSION miRNA mimic design significantly reduces possible sense strand off target effects.
  • Available as a whole human library and individual miRNA targets.

Other Notes

miRBase V18 Mature ID update: hsa-miR-21-5p

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Lina Cai et al.
Oncology letters, 15(4), 5213-5219 (2018-03-20)
Numerous studies have indicated that microRNAs (miRs), a group of small non-coding RNAs, are determining regulatory elements involved in the pathogenesis of various types of cancer, including cervical cancer (CC). Although miR-21-5p upregulation has been demonstrated to associate with tumorigenesis
Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs
Collino F., Deregibus M.C., Bruno S., Sterpone L., Aghemo G., et al.
PLoS ONE, 5 (2010)
C Probert et al.
Oncogene, 38(10), 1751-1763 (2018-10-26)
The role of extracellular vesicles (EVs) as vehicles for cell-to-cell communication between a tumour and its environment is a relatively new concept. The hypothesis that EVs may be critical in co-opting tissues by tumours to generate distant metastatic niches is

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service