HMI0254
MISSION® microRNA Mimic
hsa-miR-155
Synonym(s):
hsa-miR-155-5p
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About This Item
Recommended Products
product line
MISSION®
form
solid
mature sequence
UUAAUGCUAAUCGUGAUAGGGGU
Sanger mature/minor accession no.
Sanger microRNA accession no.
storage temp.
−20°C
Gene Information
General description
The ready-to-use MISSION miRNA mimics are small, double-stranded RNA molecules designed to mimic endogenous mature miRNA molecules when introduced into cells. miRNA are known to regulate gene expression in a variety of manners, including translational repression, mRNA cleavage and deadenylation. MISSION miRNA Mimics, a member of MISSION RNAi product family, provides miRNA researchers with a range of options from individual MISSION mimics to a full library of human miRNA mimics based on latest version of miRBase (currently hosted by the University of Manchester, previously hosted by the Sanger Institute).
- Optimized and ready for transfection.
- Novel MISSION miRNA mimic design has been functionally tested for knockdown efficiency against natural miRNA targets.
- Unique MISSION miRNA mimic design significantly reduces possible sense strand off target effects.
- Available as a whole human library and individual miRNA targets.
Biochem/physiol Actions
The miRNA hsa-miR-155-5p is a hypoxia-inducible oncomir which particularly targets the 3′UTR of the HIF1α (hypoxia-inducible factor 1-α) mRNA. It also targets pVHL (von Hippel Lindau tumour suppressor protein), thereby controlling hypoxic response pathways. The miRNA hsa-miR-155-5p controls ELK3 (ETS domain-containing protein) expression under hypoxia. It also regulates the expression of TFAM (transcription factor A, mitochondrial) and thereby regulates mitochondrial biogenesis in diploid cells. The miRNA hsa-miR-155-5p is upregulated in active MS (multiple sclerosis) lesions.
Other Notes
miRBase V18 Mature ID update: hsa-miR-155-5p
Legal Information
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Integration of MicroRNA databases to study MicroRNAs associated with multiple sclerosis.
Angerstein C
Molecular Neurobiology, 45, 520-520 (2012)
The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.
Robertson ED
PLoS ONE, 9, e113050-e113050 (2014)
Xiang Song et al.
Acta biochimica et biophysica Sinica, 51(4), 386-392 (2019-03-07)
LncRNA NEF has been proved to be a tumor suppressor in liver cancer. In the present study, we found that lncRNA NEF was downregulated and miRNA-155 was upregulated in plasma of triple-negative breast cancer (TNBC) patients compared with those in
Yujia Shi et al.
Allergy, asthma & immunology research, 10(3), 260-267 (2018-04-21)
Molecular mechanisms leading to asthma is still ill-defined. Though the function of microRNAs (miRNAs) in asthma was previously reported, the involvement of miR-155 in important features of this disease remains unknown. The present study was designed to uncover the probable
Adolfo Quiñones-Lombraña et al.
Biochimica et biophysica acta, 1852(7), 1420-1427 (2015-04-15)
The regulation of mitochondrial biogenesis is under the control of nuclear genes including the master Mitochondrial Transcription Factor A (TFAM). Recent evidence suggests that the expression of TFAM is regulated by microRNAs (miRNAs) in various cellular contexts. Here, we show
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