H9762
Haptoglobin Human, Phenotype 2-2
98-100%, essentially salt-free, lyophilized powder
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General description
Haptoglobin is an α2-globulin found in normal plasma at a concentration of 82-236 mg/dl and accounts for 0.4-2.6% of the total plasma proteins. . The monomeric form of this acute phase plasma protein is composed of four polypeptide chains: two α chains and two β chains.
Haptoglobin is an acute phase protein that scavenges hemoglobin released into the circulation. Haptoglobin, the plasma protein with highest binding affinity to hemoglobin, is mainly expressed in the liver.
Application
Haptoglobin was used to study haptoglobin expression and release by rabbit oviduct and endometrium. It was also used to analyze its localization in blastocyst extra-embryonic matrix and fluid during pre-implantation.
Other Notes
Occurs as 3 major phenotypes: type 1-1, type 2-1, type 2-2.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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A Herrler et al.
Human reproduction (Oxford, England), 19(12), 2730-2737 (2004-09-25)
Evidence is emerging that haptoglobin, an acute phase protein with immunomodulatory properties, is expressed by the endometrium of various species. The present study describes an in-depth investigation of haptoglobin expression and release in the rabbit reproductive tract and in preimplantation
I B Ross et al.
Journal of neurotrauma, 8(4), 229-238 (1991-01-01)
Previously in our laboratory, nimodipine was effective in reversing posttraumatic ischemia and promoting electrophysiologic recovery in a rat spinal cord injury (SCI) model. However, these beneficial effects were achieved when nimodipine was combined with adjuvant therapy to reverse posttraumatic hypotension
Hanne Van Gorp et al.
The Journal of general virology, 89(Pt 12), 2943-2953 (2008-11-15)
The porcine reproductive and respiratory syndrome virus (PRRSV) shows a restricted tropism for subsets of porcine macrophages in vivo. To date, two PRRSV receptors have been identified on primary macrophages, heparan sulphate for binding and sialoadhesin for binding and internalization.
Laust Dupont et al.
Progress in transplantation (Aliso Viejo, Calif.), 27(4), 386-391 (2017-12-01)
Cardiovascular disease is the leading cause of death in renal transplant recipients. An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype
C Gerbert et al.
Journal of dairy science, 101(8), 7348-7360 (2018-05-21)
Animal welfare in dairy calf husbandry depends on calf rearing and is probably improved by intensive milk feeding programs. In addition, butyrate supplementation in milk replacer (MR) stimulates postnatal growth and may affect the immune system in calves. We have
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