H8885
Hydroxyzine dihydrochloride
≥97%
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About This Item
Empirical Formula (Hill Notation):
C21H27ClN2O2 · 2HCl
CAS Number:
Molecular Weight:
447.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
218-586-3
MDL number:
Quality Level
assay
≥97%
form
powder
solubility
H2O: soluble, alcohol: soluble, chloroform: soluble
SMILES string
Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3
InChI
1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H
InChI key
ANOMHKZSQFYSBR-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269)
General description
Hydroxyzine dihydrochloride (HDH) is the first-generation antihistamine, that belongs to the piperazine class, an H1 receptor antagonist.
Application
Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.
Biochem/physiol Actions
Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2 - STOT SE 3
target_organs
Central nervous system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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COMPARATIVE ANXIOLYTIC ACTIVITY OF VARIOUS DRUGS IN EXPERIMENTAL MODELS OF RATS
Vitthal K R, et al.
International Journal of Current Research and Review, 4(24), 77-77 (2012)
Acid-base titrimetric assay of hydroxyzine dihydrochloride in pharmaceutical samples
Rajendraprasad N, et al.
Chemical Industry Times / Hua Gong Shi Kan, 16(2), 127-132 (2010)
Sunita B Chhaiya et al.
Indian journal of dermatology, venereology and leprology, 78(5), 605-610 (2012-09-11)
Ivermectin has opened a new era in the management of scabies as orally effective drug. However, topical route has been little explored for ivermectin. To compare the efficacy and safety of topical permethrin, oral ivermectin, and topical ivermectin in the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H8885-10G | 04061833811320 |