H7891
Hexammine cobalt(III) chloride
for use in transformations, X-ray crystallography and NMR
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Synonym(s):
Cobalt hexammine trichloride, Hexaamminecobalt trichloride
Linear Formula:
[Co(NH3)6]Cl3
CAS Number:
Molecular Weight:
267.48
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.52
Recommended Products
grade
for molecular biology
Quality Level
form
powder
storage temp.
room temp
SMILES string
N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Co+3]
InChI
1S/3ClH.Co.6H3N/h3*1H;;6*1H3/q;;;+3;;;;;;/p-3
InChI key
JXBGZYGSWFSYFI-UHFFFAOYSA-K
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General description
Hexammine cobalt(III) is considered an analog of fully solvated magnesium, capable of activating some enzymes that requires magnesium. It is useful in DNA condensation studies.
Application
Suitable for
- DNA condensation studies
- induction of transitions of DNA from B to A or Z forms
- induction of nucleic acid crystal growth
- stabilization of tertiary tRNA interactions
- preparation of ligation buffer
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Description
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Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 4 - Carc. 2 - Resp. Sens. 1 - Skin Sens. 1
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Filip Senigl et al.
Cell reports, 29(12), 3902-3915 (2019-12-19)
Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. We have used lentiviral SHM reporter vectors to identify regions of the genome that are susceptible ("hot") and resistant ("cold")
Tong Zhang et al.
PloS one, 7(8), e43872-e43872 (2012-09-07)
Crystal structures of Thermotoga maritima magnesium transporter CorA, reported in 2006, revealed its homo-pentameric constructions. However, the structure of the highly conserved extracellular interhelical loops remains unsolved, due to its high flexibility. We have explored the configurations of the loops
G Soslau et al.
Nucleic acids research, 14(18), 7237-7252 (1986-09-25)
These studies employed the synthetic linear DNA, poly dGdC, in the B and cobalt hexammine chloride (Co)-induced Z form to determine the effect of conformation on protein-DNA interactions. The rate of the reaction of the restriction endonucleases, Hha I and
K E Rao et al.
Journal of biomolecular structure & dynamics, 7(2), 335-345 (1989-10-01)
Interaction of the DNA binding nonintercalators Netropsin, Distamycin and the mPD derivative with Z-DNA has been studied. It has been found that environmental factors like the solvent and added cations significantly modulate the interaction of these ligands with Z-DNA. However
Tumpa Sarkar et al.
Nucleic acids research, 33(1), 143-151 (2005-01-11)
The condensation of nucleic acids into well-defined particles is an integral part of several approaches to artificial cellular delivery. Improvements in the efficiency of nucleic acid delivery in vivo are important for the development of DNA- and RNA-based therapeutics. Presently
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