All Photos(3)
Synonym(s):
(S)-2-Amino-4-hydroxybutyric acid, Hse
Linear Formula:
HOCH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
119.12
Beilstein:
1721681
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
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Assay
≥98% (TLC)
Quality Level
form
powder
color
white to off-white
mp
203 °C (dec.) (lit.)
application(s)
cell analysis
detection
SMILES string
N[C@@H](CCO)C(O)=O
InChI
1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1
InChI key
UKAUYVFTDYCKQA-VKHMYHEASA-N
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General description
L-Homoserine is a variant of serine with an additional carbon on its side chain.
Application
L-Homoserine has been used as an internal standard for neurotransmitter analysis and amino acids quantification.
Biochem/physiol Actions
L-Homoserine is synthesized by deoxidation process, catalysed by homoserine dehydrogenase. This is one of the steps in the synthesis of L-threonine. The carbon flux in in bacteria such as E. coli is maintained by this reaction.
L-Homoserine is used in the biosynthesis of methionine, threonine and isoleucine.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Reprogramming Microbial Metabolic Pathways, 288-288 (2012)
Chiral recognition of non-natural ?-amino acids
Gal JF, et al.
International Journal of Mass Spectrometry, 222(1?3), 259-267 (2003)
Neurotoxic effect of maneb in rats as studied by neurochemical and immunohistochemical parameters
Nielsen BS, et al.
Environmental Toxicology and Pharmacology, 21(3), 268-275 (2006)
Quantification of 3-deoxyglucosone (3DG) as an aging marker in natural and forced aged wines
Oliveira CM, et al.
J. Food Compos. Anal., 70?76-70?76 (2016)
D C Turnell et al.
Clinical chemistry, 28(3), 527-531 (1982-03-01)
This method for estimating clinically important amino acids in serum or urine within 40 min involves o-phthalaldehyde/2-mercaptoethanol derivatization and reversed-phase "high-pressure" liquid chromatography. Homocysteic acid is an internal standard, and homoserine and norvaline are reference peaks. For all the amino
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