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H6382

Sigma-Aldrich

Hydroxyethyl starch

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About This Item

CAS Number:
9005-27-0
MDL number:
MFCD00131356
UNSPSC Code:
12352201
PubChem Substance ID:
24895739
NACRES:
NA.25

biological source

maize

form

powder

SMILES string

OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O.OCCOC[C@H]2O[C@H](OCCO)[C@H](OCCO)[C@@H](OCCO)[C@@H]2OCCO

InChI

1S/C16H32O11.C6H12O6/c17-1-6-22-11-12-13(23-7-2-18)14(24-8-3-19)15(25-9-4-20)16(27-12)26-10-5-21;7-1-2-3(8)4(9)5(10)6(11)12-2/h12-21H,1-11H2;2-11H,1H2/t12-,13-,14+,15-,16+;2-,3-,4+,5-,6+/m11/s1

InChI key

DNZMDASEFMLYBU-RNBXVSKKSA-N

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General description

Hydroxyethyl starch is a non-ionic starch derivative. It is categorized based on its in vitro molecular weight. A 6% concentration is commonly preferred with 130 kD and 0.38 to 0.45 of molecular weight and molar substitution ratios respectively. Degree of substitution; Average of 1 -OH group per 10 glucose units converted to -OCH2CH2OH.

Application

Hydroxyethyl starch has been used to study its shear response. It has also been used as a macromolecular compound in the medium for sperm isolation, culture and cryopreservation.

Biochem/physiol Actions

Hydroxyethyl starch (HES) is a colloid used for medicinal practices that involve fluid replacement. It acts as a plasma substitute. Acute kidney failure risk is increased by the use of HES in patients with severe sepsis.

Linkage

The similar Hetastarch (q.v.) is substituted to the extent of 7-8 groups per 10 glucose units.

Preparation Note

Prepared from corn starch

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the molecular weight of Hydroxyethyl starch, Product H6382?

    Product No. H6382 is not assayed for molecular weight. But based on the starch starting material, it is assumed to be greater than 1 million.

  4. Is Hydroxyethyl starch, Product H6382, soluble in water?

    Solubility in water has been reported as less than 20 mg/mL.  A 100 mg/mL preparation in water forms an opalescent suspension.

  5. Is Hydroxyethyl starch, Product H6382, the same as Hetastarch?

    No.  Hetastarch is more highly ethoxylated and partially hydrolyzed, making it much more soluble in water.  6% solutions of hetastarch in water or buffer are used as plasma volume extenders.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

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A preliminary search for alternatives to albumin as a medium supplement for the culture of human sperm
Matson P and Tardif S
Reproductive Biology, 12(3), 329-331 (2012)
Shear-thickening fluids in biologically relevant agents
Kilbride P, et al.
Biorheology, 25(Preprint), 1-12 (2019)
Hydroxyethyl starch or saline for fluid resuscitation in intensive care
Myburgh JA
The New England Journal of Medicine, 367(20), 1901-1911 (2012)
Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
Perner A, et al.
The New England Journal of Medicine, 367(2), 124-134 (2012)
Claude Martin et al.
Anesthesiology, 118(2), 387-394 (2013-01-24)
The aim of this meta-analysis was to evaluate renal safety with the active substance of the latest generation of waxy maize-derived hydroxyethyl starch in surgical patients. The authors focused on prospective, randomized, controlled studies that documented clinically relevant variables with
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